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托品酮

托品酮用途

Tropinone 是一种生物碱,是用作合成 Atropine 的中间体。

托品酮名称

[ CAS 号 ]:
532-24-1

[ 中文名 ]:
托品酮

[ 英文名 ]:
Tropinone

[中文别名 ]:

[英文别名 ]:

Tropanon
N-methyl-3-tropanone
8-Methyl-8-azabicyclo[3.2.1]-3-octanone
3-tropinone
tropan-3-one
(1S,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-one
Tropinone
EINECS 208-530-6
Tropinon
Tropanone

托品酮生物活性

[ 描述 ]:

Tropinone 是一种生物碱,是用作合成 Atropine 的中间体。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Bedewitz MA, et al. Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization. Nat Commun. 2018 Dec 11;9(1):5281. doi: 10.1038/s41467-018-07671-3.

托品酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
217.1±0.0 °C at 760 mmHg

[ 熔点 ]:
40-44 °C(lit.)

[ 分子式 ]:
C₈H₁₃NO

[ 分子量 ]:
139.195

[ 闪点 ]:
90.0±0.0 °C

[ 精确质量 ]:
139.099716

[ PSA ]:
20.31000

[ LogP ]:
0.07

[ 外观性状 ]:
米色至棕色结晶粉末

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.505

[ 储存条件 ]:
2-8°C

托品酮MSDS

托品酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S23-S24/25-S36/37/39-S26-S22

[ 危险品运输编码 ]:
1544

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2933990090

托品酮合成路线

托品酮上下游产品

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托品酮下游产品

托品酮制备

用丁二醛与甲胺、丙酮二羧酸在碱性条件下加热环合制得。

托品酮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

托品酮文献

Toxicity of field bindweed (Convolvulus arvensis) to mice.

Vet. Hum. Toxicol. 37(5) , 452-4, (1995)

The effects of feeding high and low doses of field bindweed (Convolvulus arvensis) to mice were investigated. Bindweed contains several alkaloids, including pseudotropine, and lesser amounts of tropin...

Synthesis and applications of masked oxo-sulfinamides in asymmetric synthesis.

Org. Biomol. Chem. 10(26) , 5021-31, (2012)

This short perspective reports on the synthesis and applications of a class of chiral amino carbonyl compounds, masked oxo-sulfinamides where the amine is protected with an N-sulfinyl moiety and the c...

Biosynthesis of calystegines: 15N NMR and kinetics of formation in root cultures of Calystegia sepium.

Phytochemistry 62(3) , 325-32, (2003)

Calystegines are nortropane alkaloids bearing between three and five hydroxyl groups in various positions. [15N]Tropinone was administered to root cultures of Calystegia sepium and the incorporation i...

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托品酮