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1,3-丙二醇

1,3-丙二醇用途

1,3-Propanediol 是由微生物经过甘油发酵产生的。

1,3-丙二醇名称

[ CAS 号 ]:
504-63-2

[ 中文名 ]:
1,3-丙二醇

[ 英文名 ]:
1,3-Propanediol

[中文别名 ]:

1,3-二羟基丙烷

[英文别名 ]:

1,3-Dihydroxypropane
Propan-1,3-diol
MFCD00002949
1,3-Propane diol
propylene glycol
I,3-Propandiol
Trimethylene glycol
2-Deoxyglycerol
1,3-Propylene glycol
1,3-Propandeiol

1,3-丙二醇生物活性

[ 描述 ]:

1,3-Propanediol 是由微生物经过甘油发酵产生的。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. F. Barbirato, et al. Glycerol fermentation by a new 1,3-propanediol-producing microorganism:Enterobacter agglomerans. Applied Microbiology and Biotechnology volume 43, pages786-793(1995).

1,3-丙二醇物理化学性质

[ 密度 ]:
1.052

[ 沸点 ]:
214.4±0.0 °C at 760 mmHg

[ 熔点 ]:
-32 °C

[ 分子式 ]:
C₃H₈O₂

[ 分子量 ]:
76.094

[ 闪点 ]:
79.4±0.0 °C

[ 精确质量 ]:
76.052429

[ PSA ]:
40.46000

[ LogP ]:
-1.04

[ 外观性状 ]:
透明油性液体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.434

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
100 g/L

1,3-丙二醇MSDS

1,3-丙二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY2010000

CHEMICAL NAME :: 1,3-Propanediol

CAS REGISTRY NUMBER :: 504-63-2

BEILSTEIN REFERENCE NO. :: 0969155

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C3-H8-O2

MOLECULAR WEIGHT :: 76.11

WISWESSER LINE NOTATION :: Q3Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10930 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg/10W (Continuous)

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 50,87,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82065 No. of Facilities: 85 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 1040 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82065 No. of Facilities: 652 (estimated) No. of Industries: 14 No. of Occupations: 18 No. of Employees: 12083 (estimated) No. of Female Employees: 126 (estimated)

1,3-丙二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
38

[ 安全声明 (欧洲) ]:
S23-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
TY2010000

[ 海关编码 ]:
29053980

1,3-丙二醇合成路线

1,3-丙二醇上下游产品

1,3-丙二醇上游产品

1,3-丙二醇下游产品

1,3-丙二醇制备

精制方法用活性炭处理后分馏或与甲基环己烷共沸蒸馏可以除去甘油。若要除去1,2-丙二醇可在减压下分馏或用活性氧化铝处理。其他的精制方法尚有用碳酸钾干燥后减压蒸馏。欲得高纯度产品可用苯甲醛与1,3-丙二醇反应生成2-苯基-1,3-二烷（m.p. 47~19℃），分离后用0.5mol/L HCl（3mL/g）与2-苯基-1,3-二烷一起强烈振摇15分钟。在室温放置过夜使其分解，用碳酸钾中和后，蒸馏除去苯甲醛。残留的水溶液用氯仿连续萃取一天，萃取液用碳酸钾干燥，蒸去氯仿后即可蒸出1,3-丙二醇。

1,3-丙二醇海关

[ 海关编码 ]: 2905399001

[ 中文概述 ]:
2905399001 1,3-丙二醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%

[ Summary ]:
2905399001 propane-1,3-diol。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:5.5%。general tariff:30.0%

1,3-丙二醇文献

Activation of Tomato Bushy Stunt Virus RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids In Vitro.

J. Virol. 89(10) , 5714-23, (2015)

Similar to other positive-strand RNA viruses, tombusviruses are replicated by the membrane-bound viral replicase complex (VRC). The VRC consists of the p92 virus-coded RNA-dependent RNA polymerase (Rd...

Anomalously large isotope effect in the glass transition of water.

Proc. Natl. Acad. Sci. U. S. A. 111(49) , 17402-7, (2014)

We present the discovery of an unusually large isotope effect in the structural relaxation and the glass transition temperature Tg of water. Dielectric relaxation spectroscopy of low-density as well a...

Effect of 1,3-propanediol, organic acids, and ethanol on growth and metabolism of Clostridium butyricum DSP1.

Appl. Microbiol. Biotechnol. 99(7) , 3179-89, (2015)

Knowledge of tolerance of bacteria to toxic stress is important, especially for processes targeted at high final titers of product. Information on environmental limits and stress responses may help du...

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