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吡啶吡咯酮

吡啶吡咯酮用途

Cotinine是烟草中的一种生物碱, 也是尼古丁的主要代谢物, 用作测量烟草烟雾成分的生物指标。

吡啶吡咯酮名称

[ CAS 号 ]:
486-56-6

[ 中文名 ]:
吡啶吡咯酮

[ 英文名 ]:
Cotinine

[中文别名 ]:

[英文别名 ]:

(S)-Cotinine
(5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
(5S)-1-Methyl-5-(pyridin-3-yl)pyrrolidin-2-on
T6NJ C- ET5NVTJ A1 &&S Form
L-COTININE
cotinine
(S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
(S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one
(−)-Cotinine
2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (5S)-

吡啶吡咯酮生物活性

[ 描述 ]:

Cotinine是烟草中的一种生物碱, 也是尼古丁的主要代谢物, 用作测量烟草烟雾成分的生物指标。

[ 相关类别 ]:

研究领域 >> 其他

天然产物 >> 生物碱

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

吡啶吡咯酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
316.0±0.0 °C at 760 mmHg

[ 熔点 ]:
40-42ºC

[ 分子式 ]:
C₁₀H₁₂N₂O

[ 分子量 ]:
176.215

[ 闪点 ]:
166.7±25.9 °C

[ 精确质量 ]:
176.094955

[ PSA ]:
33.20000

[ LogP ]:
-0.23

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.556

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. May be heat sensitive - store cold.

[ 水溶解性 ]:
Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.

吡啶吡咯酮MSDS

吡啶吡咯酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN1925500

CHEMICAL NAME :: Cotinine

CAS REGISTRY NUMBER :: 486-56-6

BEILSTEIN REFERENCE NO. :: 0083099

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H12-N2-O

MOLECULAR WEIGHT :: 176.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1604 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 137,313,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 930 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 137,313,1962

吡啶吡咯酮安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
UN 1230 3/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
GN1925500

[ 海关编码 ]:
2933990090

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吡啶吡咯酮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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