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藏红T

藏红T用途

用作微量分析亚硝酸的试剂、氧化还原指示剂、酸碱指示剂、生物染色剂

藏红T名称

[ CAS 号 ]:
477-73-6

[ 中文名 ]:
碱性红 2

[ 英文名 ]:
Safranin

[中文别名 ]:

[英文别名 ]:

Safranin T
safranin A
C.I. Basic Red 2 (8CI)
Safranine
safranin Y
Basic Red 2
Gossypimine
Safranine O,certified
Safranin
EINECS 207-518-8

藏红T生物活性

[ 描述 ]:

藏红(Safranin T)是一种重要且经典的吩嗪染料。藏红在学术领域被广泛用作光谱探针和指示剂。藏红具有平面结构和阳离子电荷。它可以很容易地插入生物大分子,包括DNA和蛋白质。藏红可用作金属离子浓度测定中的氧化还原指示剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Wan H, et al. Structure characterization and optical properties investigation of the four main components of the classical phenazinium dye Safranin O. Analyst. 2019;144(24):7149-7156.

藏红T物理化学性质

[ 密度 ]:
1.00 g/mL at 20 °C

[ 分子式 ]:
C₂₀H₁₉ClN₄

[ 分子量 ]:
350.845

[ 闪点 ]:
46 °C

[ 精确质量 ]:
350.129822

[ PSA ]:
68.81000

[ LogP ]:
1.61230

[ 外观性状 ]:
暗红色粉末

[ 折射率 ]:
n20/D 1.339

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable.

[ 水溶解性 ]:
可溶

藏红TMSDS

藏红T毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SG1623000

CHEMICAL NAME :: Phenazinium, 3,7-diamino-2,8-dimethyl-5-phenyl-, chloride

CAS REGISTRY NUMBER :: 477-73-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C20-H19-N4.Cl

MOLECULAR WEIGHT :: 350.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28740 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24020 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 26940 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 2 mg/disc

REFERENCE :: TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year: 27,153,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1441 No. of Facilities: 1027 (estimated) No. of Industries: 9 No. of Occupations: 18 No. of Employees: 4314 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1441 No. of Facilities: 1253 (estimated) No. of Industries: 6 No. of Occupations: 10 No. of Employees: 22263 (estimated) No. of Female Employees: 14330 (estimated)

藏红T安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
26-39-24/25-36-16

[ 危险品运输编码 ]:
UN 1170 3/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SG1623000

[ 海关编码 ]:
32041300

藏红T合成路线

藏红T上下游产品

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藏红T下游产品

藏红T制备

以 2，5-二氨基甲苯、邻甲苯胺和苯胺为原料，首先将等摩尔的 2，5-二氨基甲苯与邻甲苯胺氧化，然后与苯胺缩合，通过精制结晶，转变成氯化物而得成品。

藏红T海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

藏红T文献

Driving cartilage formation in high-density human adipose-derived stem cell aggregate and sheet constructs without exogenous growth factor delivery.

Tissue Eng. Part A 20(23-24) , 3163-75, (2014)

An attractive cell source for cartilage tissue engineering, human adipose-derived stem cells (hASCs) can be easily expanded and signaled to differentiate into chondrocytes. This study explores the inf...

In vitro characterization of self-assembled anterior cruciate ligament cell spheroids for ligament tissue engineering.

Histochem. Cell Biol. 143(3) , 289-300, (2015)

Tissue engineering of an anterior cruciate ligament (ACL) implant with functional enthesis requires site-directed seeding of different cell types on the same scaffold. Therefore, we studied the suitab...

C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress.

Mol. Cell Biochem. 406 , 183-97, (2015)

The potential of C-phycocyanin (C-PC) to prevent cisplatin (CP)-induced kidney mitochondrial dysfunction was determined in CD-1 male mice. The CP-induced mitochondrial dysfunction was characterized by...

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藏红T