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牛乳糖神经酰胺

牛乳糖神经酰胺用途

乳糖神经酰胺(LacCer)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

牛乳糖神经酰胺名称

[ CAS 号 ]:
4682-48-8

[ 中文名 ]:
乳酰基-N-脂酰基鞘氨醇

[ 英文名 ]:
Lactosylceramides (bovine buttermilk)

[英文别名 ]:

CDH
MFCD00133445
Lactocerebrosides from bovine brain

牛乳糖神经酰胺生物活性

[ 描述 ]:

乳糖神经酰胺(LacCer)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

牛乳糖神经酰胺物理化学性质

[ 密度 ]:
1.14g/cm3

[ 沸点 ]:
1001.4ºC at 760 mmHg

[ 分子式 ]:
C₅₃H₁₀₁NO₁₃

[ 分子量 ]:
960.36800

[ 闪点 ]:
559.4ºC

[ 精确质量 ]:
959.72700

[ PSA ]:
227.86000

[ LogP ]:
8.53810

[ 折射率 ]:
1.538

[ 储存条件 ]:
-20°C

牛乳糖神经酰胺MSDS

详细MSDS(安全技术说明书)

牛乳糖神经酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FK1000000

CHEMICAL NAME :: Ceramide, 1-O-(4-O-beta-D-galactopyranosyl-beta-glucopyranosyl) -

CAS REGISTRY NUMBER :: 4682-48-8

LAST UPDATED :: 199212

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Human Fibroblast

DOSE/DURATION :: 100 umol/L

REFERENCE :: ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 199,169,1992

牛乳糖神经酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
FK1000000

牛乳糖神经酰胺文献

Streptococcus suis capsular polysaccharide inhibits phagocytosis through destabilization of lipid microdomains and prevents lactosylceramide-dependent recognition.

Infect. Immun. 80(2) , 506-17, (2012)

Streptococcus suis type 2 is a major swine pathogen and a zoonotic agent, causing meningitis in both swine and humans. S. suis infects the host through the respiratory route, reaches the bloodstream, ...

Accumulation of lactosylceramide and overexpression of a PSC833-resistant P-glycoprotein in multidrug-resistant human sarcoma cells.

Oncol. Rep. 25(4) , 1161-7, (2011)

The selection pressure for resistance to chemotherapy is accompanied by the enhanced expression of ABC proteins and increased cellular glycosphingolipid content. Thus, a possible connection between gl...

Different mechanisms are involved in apoptosis induced by melanoma gangliosides on human monocyte-derived dendritic cells.

Glycobiology 19(6) , 576-82, (2009)

Tumor escape is linked to multiple mechanisms, notably the liberation, by tumor cells, of soluble factors that inhibit the function of dendritic cells (DC). We have shown that melanoma gangliosides im...

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