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6-氮尿嘧啶

6-氮尿嘧啶用途

抑菌及阴肿瘤剂。RNA合成抑制剂。

6-氮尿嘧啶名称

[ CAS 号 ]:
461-89-2

[ 中文名 ]:
6-氮杂脲嘧啶

[ 英文名 ]:
6-Azauracil

[中文别名 ]:

[英文别名 ]:

USAF cb-30
1,2,4-Triazine-3,5-dione
EINECS 207-318-0
1,2,4-Triazine-3,5(2H,4H)-dione
3,5-dihydroxy-1,2,4-triazine
1,2,4-triazine-3,5-diol
6-aza uracile
Azauracil
2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione
ipo3834

6-氮尿嘧啶生物活性

[ 描述 ]:

1,2,4-三嗪-3,5(2H,4H)-二酮是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

6-氮尿嘧啶物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
503.4ºC at 760 mmHg

[ 熔点 ]:
274-275 °C(lit.)

[ 分子式 ]:
C₃H₃N₃O₂

[ 分子量 ]:
113.07

[ 闪点 ]:
258.3ºC

[ 精确质量 ]:
113.022530

[ PSA ]:
78.61000

[ LogP ]:
-0.59

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.749

[ 储存条件 ]:
室温

6-氮尿嘧啶MSDS

6-氮尿嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY7700000

CHEMICAL NAME :: 1,2,4-Triazine-3,5(2H,4H)-dione

CAS REGISTRY NUMBER :: 461-89-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C3-H3-N3-O2

MOLECULAR WEIGHT :: 113.09

WISWESSER LINE NOTATION :: T6NMVMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2076 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 39 gm/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - testicular tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 80 mg/L

REFERENCE :: ZBPIA9 Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung II. Naturwissenschaftliche: Allgemeine, Landwirtschaftliche und Technische Mikrobiologie. (Jena, Ger. Dem. Rep.) V.107-132, 1952-77. Volume(issue)/page/year: 130,1,1975 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975

6-氮尿嘧啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25;R36/37/38;R63

[ 安全声明 (欧洲) ]:
S26-S36-S45-S38-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XY7700000

[ 海关编码 ]:
29336980

6-氮尿嘧啶合成路线

6-氮尿嘧啶上下游产品

6-氮尿嘧啶上游产品

6-氮尿嘧啶下游产品

6-氮尿嘧啶海关

[ 海关编码 ]: 29336980

6-氮尿嘧啶文献

Rad9 interacts with Aft1 to facilitate genome surveillance in fragile genomic sites under non-DNA damage-inducing conditions in S. cerevisiae.

Nucleic Acids Res. 42(20) , 12650-67, (2014)

DNA damage response and repair proteins are centrally involved in genome maintenance pathways. Yet, little is known about their functional role under non-DNA damage-inducing conditions. Here we show t...

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.

Genes Dev. 22(20) , 2786-98, (2008)

Set2-mediated H3 K36 methylation is an important histone modification on chromatin during transcription elongation. Although Set2 associates with the phosphorylated C-terminal domain (CTD) of RNA poly...

Overruling the energy gap law: fast triplet formation in 6-azauracil.

Phys. Chem. Chem. Phys. 12(48) , 15665-71, (2010)

The photophysical properties of 6-azauracil were studied by means of ab initio quantum chemical methods. On the basis of our calculations we propose here the following mechanism for the lack of fluore...

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