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5-氨基水杨酸甲酯

5-氨基水杨酸甲酯名称

[ CAS 号 ]:
42753-75-3

[ 中文名 ]:
5-氨基水杨酸甲酯

[ 英文名 ]:
Methyl 5-amino-2-hydroxybenzoate

[英文别名 ]:

Benzoic acid, 5-amino-2-hydroxy-, methyl ester
MFCD01317557
Methyl 5-amino-2-hydroxybenzoate

5-氨基水杨酸甲酯物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
319.2±27.0 °C at 760 mmHg

[ 熔点 ]:
95-99 °C(lit.)

[ 分子式 ]:
C₈H₉NO₃

[ 分子量 ]:
167.162

[ 闪点 ]:
146.8±23.7 °C

[ 精确质量 ]:
167.058243

[ PSA ]:
72.55000

[ LogP ]:
0.56

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.606

[ 储存条件 ]:
室温，避光干燥密封

5-氨基水杨酸甲酯MSDS

5-氨基水杨酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO1683100

CHEMICAL NAME :: Salicylic acid, 5-amino-, methyl ester

CAS REGISTRY NUMBER :: 42753-75-3

BEILSTEIN REFERENCE NO. :: 2803211

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H9-N-O3

MOLECULAR WEIGHT :: 167.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,255,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,255,1965

5-氨基水杨酸甲酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H317-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36/37/38-43

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
VO1683100

[ 海关编码 ]:
2922509090

5-氨基水杨酸甲酯合成路线

5-氨基水杨酸甲酯上下游产品

5-氨基水杨酸甲酯上游产品

5-氨基水杨酸甲酯下游产品

5-氨基水杨酸甲酯海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

5-氨基水杨酸甲酯文献

[Therapeutic effect of methyl 5-aminosalicylate on experimental ulcerative colitis in rabbits].

Zhongguo Yao Li Xue Bao 11(1) , 54-6, (1990)

Using the improved Kirsner model of ulcerative colitis in rabbits, we found that the therapeutic effect of methyl 5-amino salicylate hydrochloride (M-5-AS) was similar to that of sulfasalazine (salicy...

[Teratologic studies of methyl 5-aminosalicylate and salicylazopyridine].

Zhongguo Yao Li Xue Bao 13(3) , 265-7, (1992)

Methyl 5-aminosalicylate hydrochloride (M-5-AS) at the dosages of 21, 42, 209, and 417 mg.kg-1.d-1 ig to mice during d 6-15 of pregnancy, no obvious effects on the placenta, fetus weight, sex differen...

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