2,3,5-三乙酰尿苷

2,3,5-三乙酰尿苷用途

Uridine triacetate (Tri-O-acetyl uridine) 是尿苷的口服前药。Uridine triacetate (Tri-O-acetyl uridine) 脂溶性强,在肠道内迅速吸收,在循环中迅速脱乙酰,生成游离尿苷。Uridine triacetate (Tri-O-acetyl uridine) 用于预防和治疗危及生命的 5-氟尿嘧啶和卡培他滨的毒性。Uridine triacetate (Tri-O-acetyl uridine) 提供高浓度尿苷,竞争与有毒 5-FU 代谢物。

2,3,5-三乙酰尿苷名称

[ CAS 号 ]:
4105-38-8

[ 中文名 ]:
2',3',5'-三乙酰尿苷

[ 英文名 ]:
uridine triacetate

[中文别名 ]:

[英文别名 ]:

2',3',5-TRI-ACETYLURIDINE
EINECS 223-881-5
Vistogard
Uridine 2',3',5'-triacetate
2',3',5'-Tri-O-acetyl-rU
2’,3’,5’-Triacetyluridine
Uridine, 2',3',5'-triacetate
2`,3`,5`-Tracetyluridine
TAU
2',3',5'-Tri-O-acety

2,3,5-三乙酰尿苷生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Ma WW, et al. Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Cancer. 2017 Jan 1;123(2):345-356.

[2]. Cada DJ, et al. Uridine Triacetate. Hosp Pharm. 2016 Jun;51(6):484-8.

2,3,5-三乙酰尿苷物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
124-134ºC

[ 分子式 ]:
C₁₅H₁₈N₂O₉

[ 分子量 ]:
370.311

[ 精确质量 ]:
370.101227

[ PSA ]:
142.99000

[ LogP ]:
-0.11

[ 外观性状 ]:
白色或近乎于白色结晶粉末

[ 折射率 ]:
1.552

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
可溶于：甲醇

2,3,5-三乙酰尿苷MSDS

详细MSDS(安全技术说明书)

2,3,5-三乙酰尿苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

2,3,5-三乙酰尿苷上下游产品

2,3,5-三乙酰尿苷上游产品

2,3,5-三乙酰尿苷下游产品

2,3,5-三乙酰尿苷文献

Evaluation of molecularly imprinted polymers using 2',3',5'-tri-O-acyluridines as templates for pyrimidine nucleoside recognition.

Anal. Bioanal. Chem 406(25) , 6275-84, (2014)

In this paper, we describe the synthesis and evaluation of molecularly imprinted polymers (MIPs), prepared using 2',3',5'-tri-O-acyluridines as 'dummy' templates, for the selective recognition of urid...

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