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腺苷-3',5'-环磷酸酯钠

腺苷-3',5'-环磷酸酯钠用途

环腺苷酸钠,三磷酸腺苷衍生物,是一种细胞内信号分子,负责引导细胞对细胞外信号的反应。环腺苷酸钠是许多生物过程中重要的第二信使[1][2][3]。

腺苷-3',5'-环磷酸酯钠名称

[ CAS 号 ]:
37839-81-9

[ 中文名 ]:
腺苷-3',5'-环状单磷酸钠水合物

[ 英文名 ]:
camp sodium salt

[中文别名 ]:

[英文别名 ]:

3’,5‘-Cyclic AMP sodium salt
3',5'-Cyclic AMP Sodium Salt Hydrate
MFCD00069736
CAMP SODIUM SALT

腺苷-3',5'-环磷酸酯钠生物活性

[ 描述 ]:

环腺苷酸钠,三磷酸腺苷衍生物,是一种细胞内信号分子,负责引导细胞对细胞外信号的反应。环腺苷酸钠是许多生物过程中重要的第二信使[1][2][3]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

[ 靶点 ]

Human Endogenous Metabolite

Microbial Metabolite

[体外研究]

环腺苷酸钠调节介体的生成。环腺苷酸钠抑制促炎细胞因子的表达,包括TNF-α和IL-12,并增强抗炎细胞因子IL-10的产生。

[参考文献]

[1]. G M Fimia, et al. Cyclic AMP signaling. J Cell Sci. 2001 Jun;114(Pt 11):1971-2.

[2]. Paolo Sassone-Corsi, et al. The cyclic AMP pathway. Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a011148.

[3]. Aronoff DM, et, al. Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res. 2006 Nov;26(11):827-33.

腺苷-3',5'-环磷酸酯钠物理化学性质

[ 沸点 ]:
701.5ºC at 760 mmHg

[ 熔点 ]:
219 - 220ºC

[ 分子式 ]:
C₁₀H₁₁N₅NaO₆P

[ 分子量 ]:
351.19

[ 闪点 ]:
378ºC

[ 精确质量 ]:
351.034454

[ PSA ]:
167.48000

[ LogP ]:
0.20200

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 50 mg/mL | Soluble in water (50 mg/ml).

腺苷-3',5'-环磷酸酯钠MSDS

详细MSDS(安全技术说明书)

腺苷-3',5'-环磷酸酯钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7357900

CHEMICAL NAME :: Adenosine, cyclic 3',5'-(hydrogen phosphate)-, monosodium salt

CAS REGISTRY NUMBER :: 37839-81-9

LAST UPDATED :: 199409

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H11-N5-O6-P.Na

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14300 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 1(2),15,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - ataxia

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 1(2),15,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 645 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - ataxia

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 1(2),15,1976

腺苷-3',5'-环磷酸酯钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
AU7357900

[ 海关编码 ]:
29349990

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腺苷-3',5'-环磷酸酯钠文献

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