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2-(氨甲基)吡啶

2-(氨甲基)吡啶用途

【用途一】
有机合成、药物合成

2-(氨甲基)吡啶名称

[ CAS 号 ]:
3731-51-9

[ 中文名 ]:
2-氨甲基吡啶

[ 英文名 ]:
2-Picolylamine

[中文别名 ]:

[英文别名 ]:

aminomethylpyridine
2-Methyl-3-pyridinamine
2-Pyridinemethanamine
MFCD00129044
3-Amino-2-picoline
3-Pyridinamine, 2-methyl-
1-(pyridin-2-yl)methanamine
2-Picolylamine
2-(Aminomethyl)pyridine
Pyridine, 2-(aminomethyl)-

2-(氨甲基)吡啶物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
203.0±0.0 °C at 760 mmHg

[ 熔点 ]:
20°C

[ 分子式 ]:
C₆H₈N₂

[ 分子量 ]:
108.141

[ 闪点 ]:
90.0±0.0 °C

[ 精确质量 ]:
108.068748

[ PSA ]:
24.92000

[ LogP ]:
-0.40

[ 外观性状 ]:
透明黄色棕色液体

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
SOLUBLE

2-(氨甲基)吡啶MSDS

2-(氨甲基)吡啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US1840000

CHEMICAL NAME :: Pyridine, 2-aminomethyl-

CAS REGISTRY NUMBER :: 3731-51-9

BEILSTEIN REFERENCE NO. :: 0108054

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H8-N2

MOLECULAR WEIGHT :: 108.16

WISWESSER LINE NOTATION :: T6NJ B1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 562 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

2-(氨甲基)吡啶安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S25

[ 危险品运输编码 ]:
UN 2735 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
US1840000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29333999

2-(氨甲基)吡啶合成路线

2-(氨甲基)吡啶上下游产品

2-(氨甲基)吡啶上游产品

2-(氨甲基)吡啶下游产品

2-(氨甲基)吡啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(氨甲基)吡啶文献

Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.

Bioorg. Med. Chem. 16 , 3530-6, (2008)

The first activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms associated to tumors, hCA IX and XII, with a small library of natural and non-natural amino acids as well as aroma...

Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.

Bioorg. Med. Chem. Lett. 16 , 3955-9, (2006)

The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine ...

Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.

Bioorg. Med. Chem. 15 , 5351-7, (2007)

The secretory isozyme of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VI, has been cloned, expressed, and purified in a bacterial expression system. The kinetic parameters for the CO(2) hydration r...

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