马来酸乙酰丙嗪

马来酸乙酰丙嗪用途

Acepromazine maleate, also known as Sch-10649, is a dopamine D1/2 receptor and 5-HT1A/2A receptor antagonist used to prevent nausea and induce sedation. Acepromazine maleate is discontinued.

马来酸乙酰丙嗪名称

[ CAS 号 ]:
3598-37-6

[ 中文名 ]:
乙酰丙嗪马来酸酯

[ 英文名 ]:
Acepromazine maleate

[中文别名 ]:

[英文别名 ]:

ACEPROMAZINE MALEATE
Acepromazine maleate
Acetopromazine maleate salt

马来酸乙酰丙嗪物理化学性质

[ 密度 ]:
1.155g/cm3

[ 沸点 ]:
497ºC at 760 mmHg

[ 熔点 ]:
135-136ºC

[ 分子式 ]:
C₂₃H₂₆N₂O₅S

[ 分子量 ]:
442.52800

[ 闪点 ]:
254.4ºC

[ 精确质量 ]:
442.15600

[ PSA ]:
123.45000

[ LogP ]:
4.22040

[ 外观性状 ]:
灰白色或黄色结晶粉末

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
H2O: >10mg/mL

马来酸乙酰丙嗪MSDS

详细MSDS(安全技术说明书)

马来酸乙酰丙嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB2450000

CAS REGISTRY NUMBER :: 3598-37-6

LAST UPDATED :: 199707

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C19-H22-N2-O-S.C4-H4-O4

MOLECULAR WEIGHT :: 442.57

WISWESSER LINE NOTATION :: T C666 BN ISJ B3N1&1 EV1 &OV1U1VO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 6250 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Cardiac - pulse rate increase, without fall in BP

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 11,247,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,78,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,6,1989

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,53,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,53,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1537 No. of Facilities: 315 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2207 (estimated) No. of Female Employees: 946 (estimated)

马来酸乙酰丙嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
Xn;N

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S60-S61

[ 危险品运输编码 ]:
UN 3077

[ RTECS号 ]:
2664-15-5

[ 海关编码 ]:
2934300000

马来酸乙酰丙嗪海关

[ 海关编码 ]: 2934300000

[ 中文概述 ]:
2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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