2,3,4,9-四氢-6-甲氧基-1H-吡咯[3,4-B]吲哚(HCL)
名称
[ CAS 号 ]:
35764-54-6
[ 中文名 ]:
2,3,4,9-四氢-6-甲氧基-1H-吡咯[3,4-B]吲哚(HCL)
[ 英文名 ]:
6-METHOXY-1,2,3,4-TETRAHYDRO-9 H-PYRIDO[3,4-B]INDOLE HYDROCHLORIDE
[中文别名 ]:
[英文别名 ]:
- MFCD00075570
物理化学性质
[ 密度 ]:
1.198g/cm3
[ 沸点 ]:
388.6ºC at 760mmHg
[ 熔点 ]:
288-290ºC(lit.)
[ 分子式 ]:
C12H15ClN2O
[ 分子量 ]:
238.71300
[ 闪点 ]:
188.8ºC
[ 精确质量 ]:
238.08700
[ PSA ]:
37.05000
[ LogP ]:
2.95300
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UV0795000
- CHEMICAL NAME :
- 1H-Pyrido(3,4-b)indole, 2,3,4,9-tetrahydro-6-methoxy-, monohydrochloride
- CAS REGISTRY NUMBER :
- 35764-54-6
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C12-H14-N2-O.Cl-H
- MOLECULAR WEIGHT :
- 238.74
- WISWESSER LINE NOTATION :
- T B656 EN HMT&&J LO1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 595 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,42,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 235 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,42,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 112 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,42,1978
安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302-H312-H315-H319-H332-H335
[ 警示性声明 ]:
P261-P280-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
20/21/22-36/37/38
[ 安全声明 (欧洲) ]:
S26;S36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ RTECS号 ]:
UV0795000
[ 海关编码 ]:
2933990090
海关
[ 海关编码 ]: 2933990090
[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
文献
J. Pineal Res. 49(1) , 78-85, (2010)
The protective in vivo effects of melatonin or pinoline on carbon tetrachloride (CCl(4))-induced oxidative damage were investigated in liver of rats and compared to rats injected only with CCl(4) (5 m...
Pinoline may be used as a probe for CYP2D6 activity.Drug Metab. Dispos. 37(3) , 443-6, (2009)
Pinoline, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline, is a serotonin analog that selectively inhibits the activity of monoamine oxidase-A and shows antidepressant activity. Our previous study using a...
Melatonin and pinoline prevent aluminium-induced lipid peroxidation in rat synaptosomes.J. Trace Elem. Med. Biol. 17(1) , 39-44, (2003)
The serum concentrations of aluminum, a metal potentially involved in the pathogenesis of Alzheimer's disease, increase with age. Also, intense and prolonged exposure to aluminum may result in dementi...
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公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥1354.0/100mg
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联系人:阿拉丁
产品详情:6-甲氧基-1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚盐酸盐
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相关化合物
CAS号[35764-54-6]化源网提供[2,3,4,9-四氢-6-甲氧基-1H-吡咯[3,4-B]吲哚(HCL)]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版:2,3,4,9-四氢-6-甲氧基-1H-吡咯[3,4-B]吲哚(HCL)
标题:35764-54-6_CAS号:35764-54-6_2,3,4,9-四氢-6-甲氧基-1H-吡咯[3,4-B]吲哚(HCL) - 化源网 地址:https://www.chemsrc.com/amp/cas/35764-54-6_672447.html