2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐

2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐用途

Viloxazine hydrochloride 是 Viloxazine (HY-W380450) 的非活性异构体,可作为实验中的对照化合物。Viloxazine (Viloxazin) 是一种去甲肾上腺素重摄取 (norepinephrine reuptake) 抑制剂,也是有效的 5-HT2C 激动剂和 5-HT2B 拮抗剂,对 5-HT2C 的 EC50 为 32 μM,对 5-HT2B 的 IC50 为 27 μM。Viloxazine 的作用机制主要涉及血清素能和去甲肾上腺素能通路。Viloxazine 可用于抗抑郁研究。

2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐名称

[ CAS 号 ]:
35604-67-2

[ 中文名 ]:
2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐

[ 英文名 ]:
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

[中文别名 ]:

[英文别名 ]:

Emovit
Viloxacina clorhidrato [Spanish]
EINECS 252-638-6
Viloxazine HCl
Viloxazine hydrochloride
Vivalan
Vicilan

2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Yu C, et al. New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties. J Exp Pharmacol. 2020 Aug 25;12:285-300.

[2]. Pinder RM, et al. Viloxazine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1977 Jun;13(6):401-21.

2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐物理化学性质

[ 密度 ]:
1.061g/cm3

[ 沸点 ]:
350.5ºC at 760mmHg

[ 分子式 ]:
C₁₃H₂₀ClNO₃

[ 分子量 ]:
273.76

[ 闪点 ]:
144.3ºC

[ 精确质量 ]:
273.11300

[ PSA ]:
39.72000

[ LogP ]:
2.58330

2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QE3950000

CHEMICAL NAME :: Morpholine, 2-((2-ethoxyphenoxy)methyl)-, hydrochloride

CAS REGISTRY NUMBER :: 35604-67-2

LAST UPDATED :: 199209

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C13-H19-N-O3.Cl-H

MOLECULAR WEIGHT :: 273.79

WISWESSER LINE NOTATION :: T6M DOTJ C1OR BO2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 25 mg/kg/6D

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - convulsions or effect on seizure threshold

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,96,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - sleep

REFERENCE :: JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972- Volume(issue)/page/year: 4,83,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972- Volume(issue)/page/year: 4,83,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 162 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 35,812,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972- Volume(issue)/page/year: 4,83,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 22,385,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 162 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 35,812,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972- Volume(issue)/page/year: 4,83,1976 *** REVIEWS *** TOXICOLOGY REVIEW DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 13,401,1977

2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐安全信息

[ 海关编码 ]:
2934999090

2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐上下游产品

2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐上游产品

2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐下游产品

2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%