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ITX3

ITX3用途

ITX3是无毒性的TrioN(N-terminal GEF domain of the multidomain Trio protein)抑制剂,IC50为76 uM,能体外抑制TrioN刺激的RhoG交换。

ITX3名称

[ CAS 号 ]:
347323-96-0

[ 中文名 ]:
ITX3

[ 英文名 ]:
ITX 3

ITX3生物活性

[ 描述 ]:

ITX3是无毒性的TrioN(N-terminal GEF domain of the multidomain Trio protein)抑制剂,IC50为76 uM,能体外抑制TrioN刺激的RhoG交换。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[参考文献]

[1]. Bouquier N, et al. A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem Biol. 2009 Jun 26;16(6):657-66.

[2]. Yano T, et al. Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J Cell Biol. 2011 Apr 18;193(2):319-32.

[相关活性小分子]

ITX3物理化学性质

[ 分子式 ]:
C₂₂H₁₇N₃OS

[ 分子量 ]:
371.45500

[ 精确质量 ]:
371.10900

[ PSA ]:
67.54000

[ LogP ]:
3.86440

[ 储存条件 ]:
2-8℃

ITX3安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

ITX3文献

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.

J. Cell Sci. 128 , 3041-54, (2015)

Endothelial cell-cell junctions maintain a restrictive barrier that is tightly regulated to allow dynamic responses to permeability-inducing angiogenic factors, as well as to inflammatory agents and a...

The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2.

Biol. Open 2 , 569-79, (2013)

Inflammation is characterized by endothelium that highly expresses numerous adhesion molecules to trigger leukocyte extravasation. Central to this event is increased gene transcription. Small Rho-GTPa...

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