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5'-脱氧胸苷

5'-脱氧胸苷用途

5′-Deoxythymidine是 5'位被氢取代的胸腺嘧啶形式。55′-Deoxythymidine 对枯草芽孢杆菌和金黄色葡萄球菌有效。5′-脱氧胸苷可作为研究工具用于抗病毒和抗癌研究。

5'-脱氧胸苷名称

[ CAS 号 ]:
3458-14-8

[ 中文名 ]:
5-脱氧胸苷

[ 英文名 ]:
5'-DEOXYTHYMIDINE

[英文别名 ]:

MFCD00057398
5'-Deoxythymidine

5'-脱氧胸苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. Hatano A, et al. Impact of unnatural nucleosides on the control of microbial growth. Biocontrol Sci. 2009;14(2):55-60.

5'-脱氧胸苷物理化学性质

[ 密度 ]:
1.344g/cm3

[ 熔点 ]:
192-193ºC(lit.)

[ 分子式 ]:
C₁₀H₁₃IN₂O₄

[ 分子量 ]:
352.13

[ 精确质量 ]:
226.09500

[ PSA ]:
84.32000

[ 折射率 ]:
1.559

[ 储存条件 ]:
-20°C

5'-脱氧胸苷MSDS

5'-脱氧胸苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

5'-脱氧胸苷合成路线

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5'-脱氧胸苷文献

Thymidine inhibits the growth-arrest-specific degradation of thymidine kinase protein in transfected L fibroblasts.

J. Mol. Biol. 265(2) , 153-60, (1997)

The expression of murine thymidine kinase (TK) is strictly dependent on the growth state of the cell. Expressing epitope-tagged TK in LTK cells, we have previously shown that low TK enzyme levels in G...

Membrane permeation characteristics of 5'-modified thymidine analogs.

Mol. Pharmacol. 41(5) , 950-6, (1992)

The membrane permeation characteristics of 5'-deoxythymidine (5'-ddThd) and 5'-azido-5'-deoxythymidine (5'-N3-5'-ddThd) were investigated in human erythrocytes, with an inhibitor-stop assay, at 20 deg...

Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives.

Arzneimittelforschung 53(4) , 266-71, (2003)

In this study, the synthesis of some benzoxazoles and their analogues were described and their antiviral activities were studied together with the previously synthesized 2,5,6-trisubstituted benzoxazo...

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