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N-苯甲酰基-beta-丙氨酸

N-苯甲酰基-beta-丙氨酸用途

Betamipron是一种化学化合物, 与Panipenem联用, 抑制Panipenem摄取进入肾小管, 防止肾毒性。

N-苯甲酰基-beta-丙氨酸名称

[ CAS 号 ]:
3440-28-6

[ 中文名 ]:
N-苯甲酰基-beta-丙氨酸

[ 英文名 ]:
Betamipron

[中文别名 ]:

[英文别名 ]:

3-Benzamidopropanoic acid
MFCD00037293
Benzoyl-β-alanine
3-benzamidopropionic acid
Betamipron
3-(Benzoylamino)propionic acid

N-苯甲酰基-beta-丙氨酸生物活性

[ 描述 ]:

Betamipron是一种化学化合物, 与Panipenem联用, 抑制Panipenem摄取进入肾小管, 防止肾毒性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

N-苯甲酰基-beta-丙氨酸物理化学性质

[ 密度 ]:
1.227 g/cm3

[ 沸点 ]:
469.2ºC at 760 mmHg

[ 熔点 ]:
132 °C

[ 分子式 ]:
C₁₀H₁₁NO₃

[ 分子量 ]:
193.19900

[ 闪点 ]:
237.6ºC

[ 精确质量 ]:
193.07400

[ PSA ]:
66.40000

[ LogP ]:
1.28200

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 折射率 ]:
1.557

[ 储存条件 ]:
−20°C

N-苯甲酰基-beta-丙氨酸MSDS

N-苯甲酰基-beta-丙氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY3272500

CHEMICAL NAME :: beta-Alanine, N-benzoyl-

CAS REGISTRY NUMBER :: 3440-28-6

BEILSTEIN REFERENCE NO. :: 2212769

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H11-N-O3

MOLECULAR WEIGHT :: 193.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3496 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 39(Suppl 3),140,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 gm/kg/90D-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - changes in sodium

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 39(Suppl 3),157,1991

N-苯甲酰基-beta-丙氨酸安全信息

[ WGK德国 ]:
3

[ RTECS号 ]:
AY3272500

N-苯甲酰基-beta-丙氨酸合成路线

N-苯甲酰基-beta-丙氨酸上下游产品

N-苯甲酰基-beta-丙氨酸上游产品

N-苯甲酰基-beta-丙氨酸下游产品

N-苯甲酰基-beta-丙氨酸文献

Reaction of Pseudomonas fluorescens kynureninase with beta-benzoyl-L-alanine: detection of a new reaction intermediate and a change in rate-determining step.

Biochemistry 43(11) , 3230-7, (2004)

Beta-benzoyl-DL-alanine was synthesized from alpha-bromoacetophenone and diethyl acetamidomalonate. The racemic amino acid was resolved by carboxypeptidase A-catalyzed hydrolysis of the N-trifluoroace...

Thermodynamic quantitative structure-activity relationship analysis for enzyme-ligand interactions in aqueous phosphate buffer and organic solvent.

Bioorg. Med. Chem. 9(8) , 1951-5, (2001)

Thermodynamic quantitative structure-activity relationships (QSAR) for chymotrypsin-ligand binding is developed, and the results are compared for the effects of organic solvent on the substrate specif...

Nephroprotective effect of betamipron on a new carbapenem, DA-1131, in rabbits.

Biopharm. Drug Dispos. 20(3) , 125-9, (1999)

The nephroprotective effect of betamipron (200 mg/kg) was evaluated after intravenous administration of a high dose of DA-1131 (200 mg/kg) to rabbits. Extensive tubular necrosis was observed without b...

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