3-(o-(Bis(beta-chloroethyl)amino)phenyl)-d,l-alanine

名称

[ CAS 号 ]:
342-95-0

[ 英文名 ]:
3-(o-(Bis(beta-chloroethyl)amino)phenyl)-d,l-alanine

[英文别名 ]:

tBuXPhos
tert-butylXphos
DI-T-BU-XPHOS
t-butyl X-phos

物理化学性质

[ 密度 ]:
1.32g/cm3

[ 沸点 ]:
464.4ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₁₈Cl₂N₂O₂

[ 分子量 ]:
305.20000

[ 闪点 ]:
234.7ºC

[ 精确质量 ]:
304.07500

[ PSA ]:
66.56000

[ LogP ]:
2.62530

[ 折射率 ]:
1.596

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY3400000

CHEMICAL NAME :: Alanine, 3-(o-(bis(2-chloroethyl)amino)phenyl)-, DL-

CAS REGISTRY NUMBER :: 342-95-0

LAST UPDATED :: 199203

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H18-Cl2-N2-O2

MOLECULAR WEIGHT :: 305.23

WISWESSER LINE NOTATION :: QVYZ1R BN2G2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3510 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 13,969,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18480 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 190 ug/kg

TOXIC EFFECTS :: Blood - leukopenia Blood - thrombocytopenia Blood - other changes

REFERENCE :: CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 380 ug/kg

TOXIC EFFECTS :: Blood - leukopenia Blood - other changes

REFERENCE :: CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965