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重酒石酸间羟胺

重酒石酸间羟胺用途

Metaraminol酒石酸是一种α1肾上腺素能受体激动剂，是一种有效的拟交感神经胺，用于预防和治疗低血压，尤其针对麻醉的并发症。

重酒石酸间羟胺名称

[ CAS 号 ]:
33402-03-8

[ 中文名 ]:
重酒石酸间羟胺

[ 英文名 ]:
Metaraminol bitartrate

[中文别名 ]:

酒石酸美拉明

[英文别名 ]:

2-Amino-1-(m-hydroxyphenyl)-1-propanol Bitartrate
Aramine
m-Hydroxyphenylpropanolamine Bitartrate
Metaraminol bitartrate
Pressorol
Metaradrine Bitartrate
MFCD00238763
a-(m-Hydroxyphenyl)-b-aminopropanol Bitartrate
m-Hydroxynorephedrine Bitartrate
1-(m-Hydroxyphenyl)-2-amino-1-propanol Bitartrate

重酒石酸间羟胺物理化学性质

[ 沸点 ]:
357.9ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₁₉NO₈

[ 分子量 ]:
317.292

[ 闪点 ]:
170.3ºC

[ 精确质量 ]:
317.111053

[ PSA ]:
181.54000

[ 外观性状 ]:
白色粉末

重酒石酸间羟胺MSDS

详细MSDS(安全技术说明书)

重酒石酸间羟胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN5160000

CAS REGISTRY NUMBER :: 33402-03-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C9-H13-N-O2.C4-H6-O6

MOLECULAR WEIGHT :: 317.33

WISWESSER LINE NOTATION :: ZY&YQR CQ &622 &QVYQYQVQ &621

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,820,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,820,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 117 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,820,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3427 ug/kg

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 281,89,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 99 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,820,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - hair

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 15,304,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,820,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5326 No. of Facilities: 75 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 5755 (estimated) No. of Female Employees: 5216 (estimated)

重酒石酸间羟胺安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331

[ 警示性声明 ]:
P261-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
DN5160000

[ 海关编码 ]:
2922509090

重酒石酸间羟胺海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

重酒石酸间羟胺文献

Pharmacokinetic study of three cardiovascular drugs by high-performance liquid chromatography using pre-column derivatization with 9,10-anthraquinone-2-sulfonyl chloride.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 858(1-2) , 42-8, (2007)

A new method was developed to analyze three cardiovascular drugs in rat plasma, Mexiletine hydrochloride (MXL), Methoxamine hydrochloride (MTX), and Metaraminol bitartrate (MTR), by high-performance l...

Norepinephrine and metaraminol in septic shock: a comparison of the hemodynamic effects.

Intensive Care Med. 31(5) , 634-7, (2005)

To compare the effects of norepinephrine and metaraminol on hemodynamics in septic shock patients.Open-label, controlled clinical trial in the general intensive care unit of a university-affiliated ho...

The blood-brain barrier for catecholamines - revisited.

Neurotox. Res. 11(3-4) , 261-71, (2007)

Although it is well-recognized that catecholamines are generally unable to penetrate the developed blood-brain barrier (BBB) to gain entry into brain, except at circumventricular sites where the BBB i...

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