4-羟基-L-(+)-2-苯基甘氨酸

4-羟基-L-(+)-2-苯基甘氨酸用途

Oxfenicine, also known as UK-25842, is a carnitine palmitoyltransferase I (CPT-1) inhibitor involved in fatty acid metabolism in the heart. In animal studies oxfenicine acts as a cardioprotective agent during ischemia. Oxfenicine produces changes in myocardial substrate utilisation and is attributed to the protection of ischemic stressed myocardium by shifting the cardiac metabolism with reduction of FFA (Free Fatty Acid) utilisation. This may be favourable in circumstances with limited oxygen supply.

4-羟基-L-(+)-2-苯基甘氨酸名称

[ CAS 号 ]:
32462-30-9

[ 中文名 ]:
L-(+)-对羟基苯甘氨酸

[ 英文名 ]:
oxfenicine

[中文别名 ]:

[英文别名 ]:

L-(+)-2-(4-Hydroxyphenyl)glycine
4-Hydroxy-L-(+)-2-phenylglycine
oxfenicine
4-Hydroxy-L-phenylglycine
L-P-HYDROXYPHENYGLYCINE
(aS)-a-Amino-4-hydroxybenzeneacetic Acid
Benzeneacetic acid, α-amino-4-hydroxy-, (αS)-
H-Phg(4-OH)-OH
EINECS 251-061-7
(2S)-Amino(4-hydroxyphenyl)acetic acid

4-羟基-L-(+)-2-苯基甘氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
365.8±32.0 °C at 760 mmHg

[ 熔点 ]:
240ºC (dec.)

[ 分子式 ]:
C₈H₉NO₃

[ 分子量 ]:
167.162

[ 闪点 ]:
175.0±25.1 °C

[ 精确质量 ]:
167.058243

[ PSA ]:
69.56000

[ LogP ]:
0.20

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.633

[ 储存条件 ]:
室温，密封，干燥

4-羟基-L-(+)-2-苯基甘氨酸MSDS

详细MSDS(安全技术说明书)

4-羟基-L-(+)-2-苯基甘氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922509090

4-羟基-L-(+)-2-苯基甘氨酸合成路线

详细合成路线

4-羟基-L-(+)-2-苯基甘氨酸上下游产品

4-羟基-L-(+)-2-苯基甘氨酸上游产品

4-羟基-L-(+)-2-苯基甘氨酸下游产品

4-羟基-L-(+)-2-苯基甘氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4-羟基-L-(+)-2-苯基甘氨酸文献

Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators.

Am. J. Physiol. Heart Circ. Physiol. 294(6) , H2576-86, (2008)

The role of proton (H+) production from glucose metabolism in the recovery of myocardial function during postischemic reperfusion and its alteration by insulin and other metabolic modulators were exam...

The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus.

Microbiology 152(Pt 10) , 2969-83, (2006)

The biosynthetic gene cluster for the 17 aa peptide antibiotic enduracidin has been cloned and sequenced from Streptomyces fungicidicus ATCC 21013. The 84 kb gene cluster contains 25 ORFs and is locat...

Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux.

Biochim. Biophys. Acta 1821(4) , 627-36, (2012)

Cardiac hypertrophy is characterised by an imbalance between lipid uptake and fatty acid β-oxidation leading to an accumulation of lipids, particularly triacylglycerol (TAG). It is unclear whether upt...

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