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3,5-二氯水杨酸

3,5-二氯水杨酸用途

用作医药、染料中间体

3,5-二氯水杨酸名称

[ CAS 号 ]:
320-72-9

[ 中文名 ]:
3,5-二氯水杨酸

[ 英文名 ]:
3,5-Dichloro-2-hydroxybenzoic acid

[中文别名 ]:

[英文别名 ]:

3,5-Cl2salH
3,5-Dichlorosalicylic acid
Salicylic acid,3,5-dichloro
Benzoic acid,3,5-dichloro-2-hydroxy
USAF DO-68
Benzoic acid, 3,5-dichloro-2-hydroxy-
EINECS 206-281-8
2-Hydroxy-3,5-dichlorobenzoic acid
3,5-dichloro-2-hydroxy-benzoic acid
3,5-Dichloro-2-hydroxybenzoic acid

3,5-二氯水杨酸物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
319.3±42.0 °C at 760 mmHg

[ 熔点 ]:
221-224 °C

[ 分子式 ]:
C₇H₄Cl₂O₃

[ 分子量 ]:
207.011

[ 闪点 ]:
146.9±27.9 °C

[ 精确质量 ]:
205.953751

[ PSA ]:
57.53000

[ LogP ]:
4.40

[ 外观性状 ]:
针状,菱形的棱柱

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.641

[ 储存条件 ]:
室温

3,5-二氯水杨酸MSDS

3,5-二氯水杨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO2450000

CHEMICAL NAME :: Salicylic acid, 3,5-dichloro-

CAS REGISTRY NUMBER :: 320-72-9

BEILSTEIN REFERENCE NO. :: 2210803

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H4-Cl2-O3

MOLECULAR WEIGHT :: 207.01

WISWESSER LINE NOTATION :: QVR BQ CG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

3,5-二氯水杨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
VO2450000

[ 海关编码 ]:
2918290000

3,5-二氯水杨酸合成路线

3,5-二氯水杨酸上下游产品

3,5-二氯水杨酸上游产品

3,5-二氯水杨酸下游产品

3,5-二氯水杨酸制备

由水杨酸氯化而得。将水杨酸溶解在冰醋酸中，温度控制在8-20℃，搅拌通氯约8h。通氯结束后，继续反应1h。冷至8-10℃，过滤、酸洗、水洗、烘干而得成品。

3,5-二氯水杨酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

3,5-二氯水杨酸文献

Spectral deciphering of the interaction between an intramolecular hydrogen bonded ESIPT drug, 3,5-dichlorosalicylic acid, and a model transport protein.

Phys. Chem. Chem. Phys. 14(25) , 8892-902, (2012)

The present work demonstrates a detailed characterization of the interaction of a bio-active drug molecule 3,5-dichlorosalicyclic acid (3,5DCSA) with a model transport protein Bovine Serum Albumin (BS...

Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: implications for inhibitor binding and selectivity.

Arch. Biochem. Biophys. 479(1) , 82-7, (2008)

The structure of aldehyde reductase (ALR1) in ternary complex with the coenzyme NADPH and 3,5-dichlorosalicylic acid (DCL), a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1), w...

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