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3-乙基-2-[7-(3-乙基-2-苯并噻唑啉)-1,3,5-庚三烯]碘化苯并噻唑

用途

3,3′-二乙基硫三碳菁碘化物是一种红外感光染料。3,3′-二乙基硫三碳菁碘是一种高度敏感的DNA螺旋度和序列手性报告物[1][2]。

名称

[ CAS 号 ]:
3071-70-3

[ 中文名 ]:
3,3'-二乙基硫代三碳菁碘化物

[ 英文名 ]:
3,3'-Diethylthiatricarbocyanine iodide

[中文别名 ]:

[英文别名 ]:

3,3'-diethyl-2,2'-thiadicarbocyanine iodide
DTTC IODIDE
3,3'-Diethylthiatricarbocyanine Iodide
THIATRICARBOCYANINE IODIDE,3,3'-DIETHYL
oliumiodide
DTTCI
NK-126
AURORA KA-295
MFCD00041994
3,3'-diethylthiatricarbocyanine

生物活性

[ 描述 ]:

3,3′-二乙基硫三碳菁碘化物是一种红外感光染料。3,3′-二乙基硫三碳菁碘是一种高度敏感的DNA螺旋度和序列手性报告物[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Choi JK, et al. 3,3'-diethylthiatricarbocyanine iodide: a highly sensitive chiroptical reporter of DNA helicity and sequence. Int J Mol Sci. 2011;12(11):8052-62.

[2]. J. A. Potenza, et al. Crystal and molecular structure of 3,3'-diethylthiatricarbocyanine iodide, an infrared photographic sensitizing dye. Acta Cryst. (1978). B34, 193-199.

物理化学性质

[ 熔点 ]:
211ºC (dec.)(lit.)

[ 分子式 ]:
C₂₅H₂₅IN₂S₂

[ 分子量 ]:
544.51400

[ 精确质量 ]:
544.05000

[ PSA ]:
65.29000

[ LogP ]:
3.13620

[ 外观性状 ]:
绿色粉末

[ 储存条件 ]:
避免光

MSDS

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL7045000

CHEMICAL NAME :: Benzothiazolium, 3-ethyl-2-(7-(3-ethyl-2-benzothiazolinylidene)-1,3,5- heptatrienyl)-, iodide

CAS REGISTRY NUMBER :: 3071-70-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C25-H25-N2-S2.I

MOLECULAR WEIGHT :: 544.54

WISWESSER LINE NOTATION :: T56 BNYSJ B2 CU2U2U2U1- CT56 BK DSJ B2 &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,897,1967

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H315-H319-H332-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38

[ 安全声明 (欧洲) ]:
S26;S36/S37

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
DL7045000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

合成路线

文献

Structure-activity relationship of cyanine tau aggregation inhibitors.

J. Med. Chem. 52 , 3539-47, (2009)

A structure-activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity depended on cyanine heterocycle, polymethine...

Three-dimensional fluorescence lifetime tomography.

Med. Phys. 32(4) , 992-1000, (2005)

Near-infrared fluorescence tomography using molecularly targeted lifetime-sensitive, fluorescent contrast agents have applications for early-stage cancer diagnostics. Yet, although the measurement of ...

Ionic dependence of membrane potential and glutamate receptor-linked responses in synaptoneurosomes as measured with a cyanine dye, DiS-C2-(5).

J. Neurochem. 48(2) , 552-9, (1987)

Membrane potentials of particles present in a subcellular brain preparation, called synaptoneurosomes, have been monitored by measurement of changes in the absorbance of a cyanine dye, DiS-C2-5. The m...

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