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灿烂黄

灿烂黄用途

亮黄是一种含有磺酸的重氮化合物,也是一种强效的VGLUT特异性抑制剂。亮黄色是不透膜的。然而,也有一些亮黄色类似物具有较低的细胞毒性和细胞穿透性。亮黄色类似物在海马神经元的谷氨酸能传递中起作用[1]。

灿烂黄名称

[ CAS 号 ]:
3051-11-4

[ 中文名 ]:
直接黄4

[ 英文名 ]:
Brilliant yellow

[中文别名 ]:

[英文别名 ]:

Brilliantgelb
EINECS 221-267-1
C.I.DIRECTYELLOW4
Brilliant yellow
Fenamin Yellow 3G
DIRECT YELLOW
MFCD00007489
Direct Yellow RCH
Brillantyellow
Brightyellow

灿烂黄生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[ 靶点 ]

VGLUT[1]

[参考文献]

[1]. Kehrl J, et al. Vesicular Glutamate Transporter Inhibitors: Structurally Modified Brilliant Yellow Analogs. Neurochem Res. 2017 Jun;42(6):1823-1832.

灿烂黄物理化学性质

[ 密度 ]:
1.5 g/cm3

[ 分子式 ]:
C₂₆H₁₈N₄Na₂O₈S₂

[ 分子量 ]:
624.55

[ 精确质量 ]:
624.036133

[ PSA ]:
221.06000

[ LogP ]:
8.06880

[ 外观性状 ]:
黄色-橙色粉末,无气味的

[ 折射率 ]:
1.691

[ 储存条件 ]:
室温

[ 水溶解性 ]:
水溶性：可溶

灿烂黄MSDS

详细MSDS(安全技术说明书)

灿烂黄安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
3204140000

灿烂黄制备

以4,4′-二氨基-2,2′-二苯乙烯二磺酸1mol与苯酚2mol偶合制成。

灿烂黄海关

[ 海关编码 ]: 3204140000

灿烂黄文献

Diazacoronand linked beta-cyclodextrin dimer complexes of Brilliant Yellow tetraanion and their sodium(I) analogues.

Org. Biomol. Chem. 1(5) , 887-94, (2003)

Complexation of the Brilliant Yellow tetraanion, 3(4-), by two new diazacoronand linked beta-cyclodextrin (beta CD) dimers 4,13-bis(2-(6A-deoxy-beta-cyclodextrin-6A-yl)aminooctylamidomethyl- and 4,13-...

Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults.

Environ. Sci. Pollut. Res. Int. 19(6) , 2438-47, (2012)

Valproic acid and its sodium salt (sodium valproate) are antiepileptic drugs that are sometimes used to treat chronic neuropathic pain and fibromyalgia, although they are not licensed for this use.To ...

Multilayered assemblies composed of brilliant yellow and poly(allylamine) for an optical pH sensor.

Anal. Sci. 22(8) , 1117-9, (2006)

Multilayered thin films containing poly(allylamine) (PAA) and brilliant yellow (BY) were prepared on a quartz slide by a layer-by-layer (LBL) deposition technique. The UV-visible spectra of the PAA/BY...

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灿烂黄