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L-硒代胱氨酸

L-硒代胱氨酸用途

L-硒代半胱氨酸是一种二硒化桥联氨基酸。L-硒代半胱氨酸是一种氧化还原活性硒化合物,具有抗氧化和促氧化作用。L-硒代半胱氨酸在HeLa细胞中诱导未折叠蛋白反应、内质网应激和大的细胞质空泡化,并在一系列癌细胞类型中具有细胞抑制作用[1]。

L-硒代胱氨酸名称

[ CAS 号 ]:
29621-88-3

[ 中文名 ]:
(R,R)-3,3′-二硒基-双(2-氨基丙酸) L-硒代胱氨酸

[ 英文名 ]:
selenocystine

[中文别名 ]:

[英文别名 ]:

selenocystine,(L)-isomer
selenocystine
L-Selenocystine
C6H12N2O4Se2
L-3,3'-Diselenodialanine
Seleno-L-cystine Monohydrate
seleno-DL-cystine
UNII:493154PTZ7
(l,l)-selenocystine
L-Alanine,3,3'-diselenobis

L-硒代胱氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74.Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74.

L-硒代胱氨酸物理化学性质

[ 沸点 ]:
538.3±60.0 °C at 760 mmHg

[ 熔点 ]:
224.5-229.5ºC(lit.)

[ 分子式 ]:
C₆H₁₂N₂O₄Se₂

[ 分子量 ]:
334.091

[ 闪点 ]:
279.3±32.9 °C

[ 精确质量 ]:
335.912750

[ PSA ]:
126.64000

[ LogP ]:
1.86

[ 外观性状 ]:
Powder | Yellow

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 储存条件 ]:
2-8°C

L-硒代胱氨酸MSDS

详细MSDS(安全技术说明书)

L-硒代胱氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY6032000

CHEMICAL NAME :: Alanine, 3,3'-diselenodi-, L-

CAS REGISTRY NUMBER :: 29621-88-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C6-H12-N2-O4-Se2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8463 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 108,437,1953 *** REVIEWS *** ACGIH TLV-TWA 0.2 mg(Se)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-BELGIUM:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-DENMARK:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-FINLAND:TWA 0.1 mg(Se)/m3;STEL 0.3 mg(Se)/m3 JAN 1993 OEL-GERMANY:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-HUNGARY:STEL 0.1 mg(Se)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-POLAND:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-TURKEY:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg(Se)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

L-硒代胱氨酸安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H331-H373-H410

[ 警示性声明 ]:
P261-P273-P301 + P310-P311-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R23/25

[ 安全声明 (欧洲) ]:
S28;S45;S60;S61

[ 危险品运输编码 ]:
UN 3283 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
AY6032000

[ 包装等级 ]:
III

[ 海关编码 ]:
2930909090

L-硒代胱氨酸海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

L-硒代胱氨酸文献

Determination of selenium and its compounds in marine organisms.

J. Trace Elem. Med. Biol. 29 , 91-8, (2015)

In this study, we investigate the type and quantity of selenium compounds in fish and marine organisms, using ion-pair reversed phase LC–ICP-MS, developed and applied for the analysis of Atlantic cod,...

Effects of selenium on development, survival, and accumulation in the honeybee (Apis mellifera L.).

Environ. Toxicol. Chem. 32(11) , 2584-92, (2013)

Apis mellifera L. (Hymenoptera: Apidae) is an important agricultural pollinator in the United States and throughout the world. In areas of selenium (Se) contamination, honeybees may be at risk because...

Selenocystine induces reactive oxygen species–mediated apoptosis in human cancer cells

Biomed. Pharmacother. 63(2) , 105-13, (2009)

Epidemiological and clinical studies have demonstrated that dietary supplementation of selenium (Se) could reduce the incidence of human cancers. In this study, selenocystine, a nutritionally availabl...

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