氟甲基-1,1,1,3,3,3-六氟异丙基醚

氟甲基-1,1,1,3,3,3-六氟异丙基醚用途

【用途一】
吸入麻醉剂，其麻醉效果和恩氟烷大致相同，约为氟烷的一半，诱导时间比恩氟烷和氟烷短，而觉醒时间无大差异。用于全身麻醉。

氟甲基-1,1,1,3,3,3-六氟异丙基醚作用

为含氟的吸入麻醉药。其最小肺泡内浓度（MAC），在氧及氧化亚氮的混合气体中为0.66%；在纯氧中为1.7%；与恩氟烷者相似，为氟烷者的1/2。其半数致死浓度（LC50）/MAC比恩氟烷者大。诱导时间比恩氟烷、氟烷者为短，苏醒时间三者无大差异。麻醉期间的镇痛、肌松效应与恩氟烷和氟烷者相同。本品的呼吸抑制作用较氟烷者小；对心血管系统的影响比异氟烷者小；对脑血流量、颅内压的影响与异氟烷者相似。本品不引起过敏反应，对眼粘膜刺激轻微。
以2%～4%浓度进行诱导麻醉、以3%维持时，吸入后10～15分钟血药浓度达稳态，约360μmol/L；停药5分钟后则约为90μmol/L；停药60分钟后为约15μmol/L。血浆消除t1/2呈三相；2.7分钟、9.04分钟、30.7分钟。血/气分配系数为0.63（恩氟烷者为1.9，氟烷者为3.2）。本品主要经呼气排泄，停止吸入1小时后约40%以原形经呼气排出。它在体内可被代谢为无机氟由尿排出，按尿中氟量计，其代谢率为2.89%，比恩氟烷者（0.96%）高，比氟烷（15.7%）低。
临床上，七氟烷作为全身麻醉药应用。

氟甲基-1,1,1,3,3,3-六氟异丙基醚名称

[ CAS 号 ]:
28523-86-6

[ 中文名 ]:
七氟烷

[ 英文名 ]:
sevoflurane

[中文别名 ]:

[英文别名 ]:

Sevoness
Sevofrane
R-E 347
mr6s4
347mmzEbg
fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether
Ultane
Sevoflurane
Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-
Sevorane

氟甲基-1,1,1,3,3,3-六氟异丙基醚物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
49.5±35.0 °C at 760 mmHg

[ 熔点 ]:
50-60ºC

[ 分子式 ]:
C₄H₃F₇O

[ 分子量 ]:
200.055

[ 闪点 ]:
-11.4±21.8 °C

[ 精确质量 ]:
200.007217

[ PSA ]:
9.23000

[ LogP ]:
2.48

[ 外观性状 ]:
无色油状

[ 蒸汽压 ]:
311.5±0.1 mmHg at 25°C

[ 折射率 ]:
1.266

[ 储存条件 ]:
库房通风低温干燥,与食品添加剂分开存放

氟甲基-1,1,1,3,3,3-六氟异丙基醚MSDS

详细MSDS(安全技术说明书)

氟甲基-1,1,1,3,3,3-六氟异丙基醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KO0737000

CHEMICAL NAME :: Ether, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-

CAS REGISTRY NUMBER :: 28523-86-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H3-F7-O

MOLECULAR WEIGHT :: 200.07

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28800 ppm/3H

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - hair

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5497,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28300 ppm/3H

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - hair

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5497,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 6600 ppm/3H

SEX/DURATION :: male 64 day(s) pre-mating female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5505,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 2 pph/3H

SEX/DURATION :: male 9 week(s) pre-mating female 2 week(s) pre-mating female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5505,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1 pph/3H

SEX/DURATION :: male 9 week(s) pre-mating female 2 week(s) pre-mating female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5505,1987

氟甲基-1,1,1,3,3,3-六氟异丙基醚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
UN 3334

[ RTECS号 ]:
KO0737000

氟甲基-1,1,1,3,3,3-六氟异丙基醚合成路线

详细合成路线

氟甲基-1,1,1,3,3,3-六氟异丙基醚上下游产品

氟甲基-1,1,1,3,3,3-六氟异丙基醚上游产品

氟甲基-1,1,1,3,3,3-六氟异丙基醚下游产品

氟甲基-1,1,1,3,3,3-六氟异丙基醚制备

【方法一】
以六氟丙酮为原料，在钯一炭催化下氢化得六氟异丙醇。六氟异丙醇用甲醛、氟化氢和硫酸反应，即可得七氟烷。
也可先和溴乙酸反应后，再用三氟化溴处理，得七氟烷。

氟甲基-1,1,1,3,3,3-六氟异丙基醚文献

Propofol increases morbidity and mortality in a rat model of sepsis.

Crit. Care 19 , 45, (2015)

Severe sepsis is associated with approximately 50% mortality and accounts for tremendous healthcare costs. Most patients require ventilatory support and propofol is commonly used to sedate mechanicall...

Protective effect of curcumin against contrast induced nephropathy in rat kidney: what is happening to oxidative stress, inflammation, autophagy and apoptosis?

Eur. Rev. Med. Pharmacol. Sci. 18(4) , 461-70, (2014)

Currently, the number of imaging and interventional procedures that use contrast agents (CAs) is gradually increasing. Oxidative stress plays a significant role in its pathophysiology. Curcumin (CC) i...

Generation of suppressive blood cells for control of allograft rejection.

Clin. Sci. 128(9) , 593-607, (2015)

Our previous studies in rats showed that incubation of monocytic dendritic cells (DCs) with the chemotherapeutic drug mitomycin C (MMC) renders the cells immunosuppressive. Donor-derived MMC-DCs injec...

更多文献