<生产厂家价格>

2-乙酰基-1-B-(L-天冬酰胺)-1,2-双脱氧-D-葡萄糖

用途

H-Asn(glcnac-beta-D)-OH是尿中存在的内源性代谢产物,可用于NGLY1-CDDG[1][2]的研究。

名称

[ CAS 号 ]:
2776-93-4

[ 中文名 ]:
2-乙酰基-1-B-(L-天冬酰胺)-1,2-双脱氧-D-葡萄糖

[ 英文名 ]:
N-Asn

[英文别名 ]:

N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine

生物活性

[ 描述 ]:

H-Asn(glcnac-beta-D)-OH是尿中存在的内源性代谢产物,可用于NGLY1-CDDG[1][2]的研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。

[参考文献]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Haijes HA, et al. Aspartylglycosamine is a biomarker for NGLY1-CDDG, a congenital disorder of deglycosylation. Mol Genet Metab. 2019 Aug;127(4):368-372.

物理化学性质

[ 密度 ]:
1.53g/cm3

[ 沸点 ]:
818.5ºC at 760mmHg

[ 分子式 ]:
C₁₂H₂₁N₃O₈

[ 分子量 ]:
335.31000

[ 闪点 ]:
448.8ºC

[ 精确质量 ]:
335.13300

[ PSA ]:
191.44000

[ 蒸汽压 ]:
4.86E-31mmHg at 25°C

[ 折射率 ]:
1.6

[ 储存条件 ]:
2-8°C

安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

上下游产品

上游产品

下游产品

文献

Synthesis of N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine analogues. n-Butyramide, 3-chloropropionamide, 3-aminopropionamide, and isovaleramide analogues.

Carbohydr. Res. 331(4) , 439-44, (2001)

The syntheses of four analogues of N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine are described. Activated carboxylic acids were reacted with 2-acetamido-2-deoxy-beta-D-glucopyranosylamin...

Aspartylglycosaminuria: biochemistry and molecular biology.

Biochim. Biophys. Acta 1455(2-3) , 139-54, (1999)

Aspartylglucosaminuria (AGU, McKusick 208400) is an autosomal recessive lysosomal storage disease caused by defective degradation of Asn-linked glycoproteins. AGU mutations occur in the gene (AGA) for...

Angiokeratoma corporis diffusum in a Spanish patient with aspartylglucosaminuria.

Br. J. Dermatol. 147(4) , 760-4, (2002)

Angiokeratoma corporis diffusum (ACD), initially considered to be synonymous with Fabry's disease, represents a well-known cutaneous marker of some other lysosomal enzyme disorders. Aspartylglucosamin...

更多文献