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Tropatepine

Tropatepine用途

托伐他平是一种抗胆碱能毒蕈碱拮抗剂,可以用作抗帕金森病药物[1]。托伐他平用于对抗由抗精神病药物引起的锥体外系综合征[2]。

Tropatepine名称

[ CAS 号 ]:
27574-24-9

[ 英文名 ]:
Tropatepine

[英文别名 ]:

Tropatepine生物活性

[ 描述 ]:

托伐他平是一种抗胆碱能毒蕈碱拮抗剂,可以用作抗帕金森病药物[1]。托伐他平用于对抗由抗精神病药物引起的锥体外系综合征[2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. P Celsis, et al. Effect of tropatepine, an anticholinergic drug, on regional cerebral blood flow in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 1989 Jul;52(7):917-8.

[2]. P Arnoux, et al. Simultaneous determination of tropatepine and its major metabolites by high-performance liquid chromatographic-mass spectrometric identification. Application to metabolic and kinetic studies. J Chromatogr. 1986 Aug 22;381(1):75-82.

Tropatepine物理化学性质

[ 密度 ]:
1.19g/cm3

[ 沸点 ]:
493.1ºC at 760mmHg

[ 分子式 ]:
C₂₂H₂₃NS

[ 分子量 ]:
333.49000

[ 闪点 ]:
252ºC

[ 精确质量 ]:
333.15500

[ PSA ]:
28.54000

[ LogP ]:
5.28870

[ 蒸汽压 ]:
7.23E-10mmHg at 25°C

[ 折射率 ]:
1.654

Tropatepine毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CL5608700

CHEMICAL NAME :: 8-Azabicyclo(3.2.1)octane, 3-dibenzo(b,e)thiepin-11(6H)-ylidene-8-methyl-

CAS REGISTRY NUMBER :: 27574-24-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H23-N-S

MOLECULAR WEIGHT :: 333.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3725415

Tropatepine安全信息

[ 海关编码 ]:
2934999090

Tropatepine海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%