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异康唑

异康唑名称

[ CAS 号 ]:
27523-40-6

[ 中文名 ]:
异康唑

[ 英文名 ]:
Isoconazole

[中文别名 ]:

邻氯益康唑

[英文别名 ]:

Travogyn
Isoconazol
Travogen
fazol
Isoconazole
Isoconazolum

异康唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
555.1±50.0 °C at 760 mmHg

[ 分子式 ]:
C₁₈H₁₄Cl₄N₂O

[ 分子量 ]:
416.129

[ 闪点 ]:
289.5±30.1 °C

[ 精确质量 ]:
413.986023

[ PSA ]:
27.05000

[ LogP ]:
5.93

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.625

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Practically insoluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent).

异康唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI4775700

CHEMICAL NAME :: 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,6-dichlorophenyl)meth oxy)ethyl)-

CAS REGISTRY NUMBER :: 27523-40-6

LAST UPDATED :: 199303

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H14-Cl4-N2-O

MOLECULAR WEIGHT :: 416.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 189 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 13,195,1990

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异康唑文献

Tinea corporis of the shin and chest successfully treated with a topical antifungal and corticosteroid cream.

Mycoses 51 Suppl 4 , 34-6, (2008)

The effective use of isoconazole nitrate and diflucortolone valerate cream in the treatment of inguino-femoral skin fold mycosis.

Mycoses 51 Suppl 4 , 29-31, (2008)

Treatment of candidal intertrigo with a topical combination of isoconazole nitrate and diflucortolone valerate.

Mycoses 51 Suppl 4 , 42-3, (2008)

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异康唑