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直接蓝1

直接蓝1用途

1. 主要用于棉、麻、粘胶等纤维素织物的染色，也可用于蚕丝、锦纶及粘/锦混纺织物染色，还可用于纸张和生物染色，并可用于制造墨水。

2. 主要用于棉、粘胶、麻等织物的染色，也可用于蚕丝、锦纶、纸浆和生物的染色

直接蓝1名称

[ CAS 号 ]:
2610-05-1

[ 中文名 ]:
滂胺天蓝

[ 英文名 ]:
Direct Blue 1

[中文别名 ]:

[英文别名 ]:

paperblue6b
modrprima1
CartaBlue2G
Direct Blue 1
Direct Blue 1 Pontamine sky blue
Chicago Sky Blue
nsb6b
Chicago Sky Blue 6B
Pontamine Sky Blue 6B
EINECS 220-026-8

直接蓝1生物活性

[ 描述 ]:

Direct Blue 1 (Chicago Sky Blue 6B) 是免疫荧光组织化学中背景自体荧光的一种复染料。Direct Blue 1 在结构上与谷氨酸盐有关,是一种有效且具有竞争性的 VGLUT 抑制剂,不影响质膜转运体。Direct Blue 1 是第一个能够抑制 Aβ 结合的小分子 PrP 配体。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344.

[2]. Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658.

[3]. Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028.

直接蓝1物理化学性质

[ 分子式 ]:
C₃₄H₂₄N₆Na₄O₁₆S₄

[ 分子量 ]:
992.804

[ 精确质量 ]:
991.972229

[ PSA ]:
422.72000

[ LogP ]:
10.18560

[ 外观性状 ]:
绿色蓝色粉末

[ 储存条件 ]:
Store at RT

直接蓝1MSDS

详细MSDS(安全技术说明书)

直接蓝1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6430000

CHEMICAL NAME :: 6,8-Naphthalenedisulfonic acid, 3,3'-((3,3'-dimethoxy-4,4'-biphenylene)bis(azo))bis( 5-amino-4-hydroxy-, tetrasodium salt

CAS REGISTRY NUMBER :: 2610-05-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C34-H28-N6-O16-S4.4Na

MOLECULAR WEIGHT :: 996.88

WISWESSER LINE NOTATION :: L66J BZ CSWO ESWO JQ INUNR BO1 DR CO1 DNUN- IL66J BZ CSWO ESWO JQ &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2260 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 140 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,103,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2162 No. of Facilities: 53 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 1141 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2162 No. of Facilities: 156 (estimated) No. of Industries: 7 No. of Occupations: 14 No. of Employees: 10195 (estimated) No. of Female Employees: 6491 (estimated)

直接蓝1安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H350

[ 警示性声明 ]:
P201-P308 + P313

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 3143

[ WGK德国 ]:
3

[ RTECS号 ]:
QJ6430000

直接蓝1制备

由联大茴香胺重氮化后，再与芝加哥SS酸进行偶合，经盐析、过滤及干燥而得。公斤/吨联大茴香胺（100%） 105芝加哥SS酸（100%） 320亚硝酸钠 70盐酸 110纯碱 120

直接蓝1文献

A comparison of the contrast stains, Chicago blue, chlorazole black, and Parker ink, for the rapid diagnosis of skin and nail infections.

Int. J. Dermatol. 51(8) , 935-8, (2012)

The cheapest, most rapid method for the diagnosis of mycotic skin and nail infections is direct examination of samples using a KOH preparation. The standard KOH wet mount lacks a color contrast. Vario...

Short-term in vivo evaluation of novel vital dyes for intraocular surgery.

Retina (Philadelphia, Pa.) 26(6) , 673-8, (2006)

To evaluate the staining characteristics and safety of potential new dyes for intraocular surgery in porcine eyes.Four dyes in different solutions (light green SF yellowish [LGSF]: 2%; copper(II) phth...

Administration of novel dyes for intraocular surgery: an in vivo toxicity animal study.

Invest. Ophthalmol. Vis. Sci. 47(8) , 3573-8, (2006)

To investigate the effect of intravitreal injections of new vital dyes on the retina, the retinal pigment epithelium (RPE) and the choroid in an in vivo rat model.Rats were injected intravitreally wit...

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