分散橙1

分散橙1用途

DO1, also known as Disperse Orange 1, is an anti-amyloid agent which potently delays both seeded and non-seeded Aβ42 polymerization at substoichiometric concentrations, thereby disrupting preformed fibrillar assemblies of synthetic Aβ42 peptides.

分散橙1名称

[ CAS 号 ]:
2581-69-3

[ 中文名 ]:
分散橙 1

[ 英文名 ]:
disperse orange 1

[中文别名 ]:

[英文别名 ]:

Disperse Orange 5R
EINECS 219-954-6
4-(4-Nitrophenylazo)diphenylamine
Vonteryl Red 4G
Acetate Orange 5R
Resolin Orange 5R
4-[(4-nitrophenyl)azo]-N-phenyl-benzenamine
Miketon Fast Orange 5R
[4-(4-nitro-phenylazo)-phenyl]-phenyl-amine
Palanil Orange 5R

分散橙1物理化学性质

[ 密度 ]:
1.24g/cm3

[ 沸点 ]:
535ºC at 760mmHg

[ 熔点 ]:
160ºC

[ 分子式 ]:
C₁₈H₁₄N₄O₂

[ 分子量 ]:
318.32900

[ 闪点 ]:
277.4ºC

[ 精确质量 ]:
318.11200

[ PSA ]:
82.57000

[ LogP ]:
6.35000

[ 蒸汽压 ]:
1.6E-11mmHg at 25°C

[ 折射率 ]:
1.642

分散橙1MSDS

详细MSDS(安全技术说明书)

分散橙1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JJ9700000

CHEMICAL NAME :: Diphenylamine, 4-((p-nitrophenyl)azo)-

CAS REGISTRY NUMBER :: 2581-69-3

BEILSTEIN REFERENCE NO. :: 0758695

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H14-N4-O2

MOLECULAR WEIGHT :: 318.36

WISWESSER LINE NOTATION :: WNR DNUNR DMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 31 gm/kg/88W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors

REFERENCE :: ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 57,530,1951 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0746 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 741 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0754 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 741 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0754 No. of Facilities: 55 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1125 (estimated) No. of Female Employees: 78 (estimated)

分散橙1安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
37/39-26-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
JJ9700000

[ 海关编码 ]:
2927000090

分散橙1合成路线

详细合成路线

分散橙1上下游产品

分散橙1上游产品

分散橙1下游产品

分散橙1海关

[ 海关编码 ]: 2927000090

[ 中文概述 ]:
2927000090 其他重氮化合物、偶氮化合物等（包括氧化偶氮化合物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

分散橙1文献

Patch testing with the textile dyes Disperse Orange 1 and Disperse Yellow 3 and some of their potential metabolites, and simultaneous reactions to para-amino compounds.

Contact Dermatitis 67(3) , 130-40, (2012)

It is known that, in vitro, human skin bacteria are able to split disperse azo dyes into the corresponding aromatic amines, some of which are sensitizers in the local lymph node assay. We hypothesize ...

Chlorination treatment of aqueous samples reduces, but does not eliminate, the mutagenic effect of the azo dyes Disperse Red 1, Disperse Red 13 and Disperse Orange 1

Mutat. Res. 703(2) , 200-8, (2010)

The treatment of textile effluents by the conventional method based on activated sludge followed by a chlorination step is not usually an effective method to remove azo dyes, and can generate products...

Textile dyes Disperse Orange 1 and Yellow 3 contain more than one allergen as shown by patch testing with thin-layer chromatograms.

Dermatitis 22(6) , 335-43, (2011)

It is known that some patch-test preparations containing disperse dyes contain impurities with unknown relevance for the development or elicitation of contact allergy.To evaluate the significance of t...

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