<生产厂家价格>

1-(2-三氟甲基苯基)咪唑

1-(2-三氟甲基苯基)咪唑用途

TRIM是一种有效的一氧化氮合酶抑制剂。TRIM在体外抑制小鼠小脑nNOS和大鼠肺iNOS,IC50值分别为28.2和27.0µM。抗抑郁和抗焦虑作用[1][2]。

1-(2-三氟甲基苯基)咪唑名称

[ CAS 号 ]:
25371-96-4

[ 中文名 ]:
1-(2-三氟甲基苯基)咪唑

[ 英文名 ]:
1-(2-(trifluoromethyl)phenyl)-1h-imidazole

[中文别名 ]:

[英文别名 ]:

1-[2-(Trifluoromethyl)phenyl]-1H-imidazole
1-(2-(trifluoromethyl)phenyl)-1h-imidazole
1-[2-(Trifluoromethyl)phenyl]imidazole
Trim
MFCD00041206
1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]-
1H-Imidazole, 1-(2-(trifluoromethyl)phenyl)-

1-(2-三氟甲基苯基)咪唑生物活性

[ 描述 ]:

TRIM是一种有效的一氧化氮合酶抑制剂。TRIM在体外抑制小鼠小脑nNOS和大鼠肺iNOS,IC50值分别为28.2和27.0µM。抗抑郁和抗焦虑作用[1][2]。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

研究领域 >> 神经疾病

[体外研究]

TRIM是一种相对较弱的eNOS抑制剂(IC501057.5µM)[1]。

[参考文献]

[1]. Handy RL, et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116(5):2349-2350.

[2]. Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res. 2003;140(1-2):141-147.

1-(2-三氟甲基苯基)咪唑物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
288.3±40.0 °C at 760 mmHg

[ 熔点 ]:
43 °C

[ 分子式 ]:
C₁₀H₇F₃N₂

[ 分子量 ]:
212.171

[ 闪点 ]:
128.2±27.3 °C

[ 精确质量 ]:
212.056137

[ PSA ]:
17.82000

[ LogP ]:
2.55

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.522

[ 储存条件 ]:
2-8°C

1-(2-三氟甲基苯基)咪唑MSDS

详细MSDS(安全技术说明书)

1-(2-三氟甲基苯基)咪唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933290090

1-(2-三氟甲基苯基)咪唑海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-(2-三氟甲基苯基)咪唑文献

Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin.

Analyst 140(9) , 3113-20, (2015)

Curcumin is a versatile anti-inflammatory and anti-cancer agent known for its low bioavailability, which could be improved by developing materials capable of binding and releasing drug in a controlled...

Cholesterol-based polymeric monolithic columns for capillary liquid chromatography.

J. Chromatogr. A. 1373 , 114-23, (2014)

A novel, cholesterol-based polymeric monolithic stationary phase for capillary liquid chromatography, was prepared by thermally initiated in-situ polymerization. Cholesteryl methacrylate (CholMA) was ...

Robust naphthyl methacrylate monolithic column for high performance liquid chromatography of a wide range of solutes.

J. Chromatogr. A. 1409 , 166-72, (2015)

An organic monolithic column based on the co-polymerization of 2-naphthyl methacrylate (NAPM) as the functional monomer and trimethylolpropane trimethacrylate (TRIM) as the crosslinker was introduced ...

更多文献