8-溴腺苷-3',5'-环单磷酸

8-溴腺苷-3',5'-环单磷酸用途

8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.

8-溴腺苷-3',5'-环单磷酸名称

[ CAS 号 ]:
23583-48-4

[ 中文名 ]:
8-溴腺苷3′,5′-环单磷酸

[ 英文名 ]:
8-bromo-Cyclic AMP

[中文别名 ]:

8-溴腺苷-3,5-环单磷酸

[英文别名 ]:

8-bromo-cAMP
Cyclic amp,8-bromo
EINECS 245-760-6
8-BR-CAMP
8-BROMOADENOSINE 3' 5'-CYCLIC
B-cAMP
MFCD00075580
8-bromo-adenosine-3',5'-cyclic monophosphate
8-Br-cyclic AMP
8-Bromo-cyclic 3',5'-amp

8-溴腺苷-3',5'-环单磷酸物理化学性质

[ 密度 ]:
2.8 g/cm3

[ 沸点 ]:
741.9ºC at 760 mmHg

[ 熔点 ]:
254ºC (dec.)(lit.)

[ 分子式 ]:
C₁₀H₁₁BrN₅O₆P

[ 分子量 ]:
408.10200

[ 闪点 ]:
402.5ºC

[ 精确质量 ]:
406.96300

[ PSA ]:
164.65000

[ LogP ]:
0.52630

[ 外观性状 ]:
Powder | Pale Brown

[ 蒸汽压 ]:
4.12E-23mmHg at 25°C

[ 折射率 ]:
2.037

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
aqueous base: soluble

8-溴腺苷-3',5'-环单磷酸MSDS

8-溴腺苷-3',5'-环单磷酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29349990

8-溴腺苷-3',5'-环单磷酸合成路线

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8-溴腺苷-3',5'-环单磷酸文献

Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain.

Biochim. Biophys. Acta 1853(1) , 183-91, (2015)

In mammalian cells the nuclear-encoded subunits of complex I are imported into mitochondria, where they are assembled with mt-DNA encoded subunits in the complex, or exchanged with pre-existing copies...

Antipruritic mechanisms of topical E6005, a phosphodiesterase 4 inhibitor: inhibition of responses to proteinase-activated receptor 2 stimulation mediated by increase in intracellular cyclic AMP.

J. Dermatol. Sci. 76(3) , 206-13, (2014)

Phosphodiesterase 4 (PDE4), which catalyses the conversion of cyclic adenosine 3',5'-monophosphate (cAMP) to 5'-AMP, plays a critical role in the pathogenesis of inflammatory disorders. Pruritus is th...

T-2 toxin regulates steroid hormone secretion of rat ovarian granulosa cells through cAMP-PKA pathway.

Toxicol. Lett. 232(3) , 573-9, (2015)

T-2 toxin is a secondary metabolite produced by Fusarium genus and is a common contaminant in food and feedstuffs of cereal origin. In porcine granulosa cells(GC), T-2 toxin has been shown to inhibit ...

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