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克氏千里光碱

克氏千里光碱用途

Senkirkin 是来自 Tussilago farfara 一种吡咯里西啶生物碱,可诱导人淋巴细胞染色体损伤.

克氏千里光碱名称

[ CAS 号 ]:
2318-18-5

[ 中文名 ]:
氧化苦参碱

[ 英文名 ]:
Senkirkine

[中文别名 ]:

[英文别名 ]:

renardin
RENARIDINE
Kushenin
Senkarkane
SENKIKIN

克氏千里光碱生物活性

[ 描述 ]:

Senkirkin 是来自 Tussilago farfara 一种吡咯里西啶生物碱,可诱导人淋巴细胞染色体损伤.

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. C Kraus, G Abel, et al. [Pyrrolizidine Alkaloids With Chromosome-Damaging Effects on Human Lymphocytes in Vitro]. Planta Med. 1985 Apr;(2):89-91.

克氏千里光碱物理化学性质

[ 密度 ]:
1.22g/cm3

[ 沸点 ]:
604.9ºC at 760 mmHg

[ 熔点 ]:
198ºC

[ 分子式 ]:
C₁₉H₂₇NO₆

[ 分子量 ]:
365.42100

[ 闪点 ]:
319.6ºC

[ 精确质量 ]:
365.18400

[ PSA ]:
93.14000

[ LogP ]:
0.94740

[ 蒸汽压 ]:
3.72E-17mmHg at 25°C

[ 折射率 ]:
1.546

[ 储存条件 ]:
?20°C

克氏千里光碱MSDS

详细MSDS(安全技术说明书)

克氏千里光碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT5960000

CHEMICAL NAME :: Senecionanium, 8,12-dihydroxy-4-methyl-11,16-dioxo-

CAS REGISTRY NUMBER :: 2318-18-5

LAST UPDATED :: 199510

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C19-H27-N-O6

MOLECULAR WEIGHT :: 365.47

WISWESSER LINE NOTATION :: T55-12- 1A Q EK IOVY OVO BUTJ DQ E1 KU2 M1 NQ N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1320 mg/kg/56W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 600 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 142,209,1985 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,231,1983 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,327,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW PPTCBY Proceedings of the International Symposium of the Princess Takamatsu Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku, Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 9,79,1979

克氏千里光碱安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
UN 1544

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

克氏千里光碱文献

Diversity of pyrrolizidine alkaloids in native and invasive Senecio pterophorus (Asteraceae): implications for toxicity.

Phytochemistry 108 , 137-46, (2014)

Changes in plant chemical defenses after invasion could have consequences on the invaded ecosystems by modifying the interactions between plants and herbivores and facilitating invasion success. Howev...

Determination of senkirkine and senecionine in Tussilago farfara using microwave-assisted extraction and pressurized hot water extraction with liquid chromatography tandem mass spectrometry.

Talanta 79(2) , 539-46, (2009)

Tussilago farfara (Kuan Donghua) is an important Chinese herbal medicine which has been shown to contain many bioactive compounds and widely used to relieve cough and resolve phlegm. However, besides ...

Interplant alkaloid variation and Senecio vernalis toxicity in cattle.

Vet. Hum. Toxicol. 43(3) , 147-51, (2001)

Senecio vernalis and other plants containing pyrrolizidine alkaloids (PA) are implicated in the poisoning of cattle. The liver is a known target organ. In this study the content of the alkaloids senec...

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