Bostrycin

Bostrycin用途

Bostrycin is an anthraquinone with antibacterial, antiproliferative, and phytotoxic properties. It is active against Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Bostrycin inhibits proliferation of A549 lung adenocarcinoma cells as well as halts the cell cycle at the G0/G1 phase and induces apoptosis in A549 cells. Bostrycin has been used as a cross-linking agent for protein immobilization that retains bacteriostatic activity when immobilized on nonwoven polypropylene fabric.

Bostrycin名称

[ CAS 号 ]:
21879-81-2

[ 英文名 ]:
Bostrycin

[英文别名 ]:

(+)-bostrycin

Bostrycin物理化学性质

[ 分子式 ]:
C₁₆H₁₆O₈

[ 分子量 ]:
336.29300

[ 精确质量 ]:
336.08500

[ PSA ]:
144.52000

Bostrycin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB8068000

CHEMICAL NAME :: Anthraquinone, 1,2,3,4-tetrahydro-1-beta,2-beta,3-beta,5,8-pentahydr oxy-6-methoxy-3-methy l-

CAS REGISTRY NUMBER :: 21879-81-2

LAST UPDATED :: 198211

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H16-O8

MOLECULAR WEIGHT :: 336.32

WISWESSER LINE NOTATION :: L C666 BV IV&&TJ DQ EO1 GQ KQ LQ MQ M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,231,1980