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二烯丙基二硫醚

二烯丙基二硫醚用途

二烯丙基二硫抑制人角鲨烯单加氧酶,角鲨烯环氧化的IC50为400μM[1]。

二烯丙基二硫醚名称

[ CAS 号 ]:
2179-57-9

[ 中文名 ]:
二烯丙基二硫

[ 英文名 ]:
Diallyl disulfide

[中文别名 ]:

[英文别名 ]:

2-Propenyl disulfide
3-(prop-2-en-1-yldisulfanyl)prop-1-ene
Diallyl disulfide
EINECS 218-548-6
disulfide, diallyl
Diallyldisulfide
diallyic disulfide
3-(Allyldisulfanyl)prop-1-ene
Allyl disulfide
Disulfide,di-2-propenyl

二烯丙基二硫醚生物活性

[ 描述 ]:

二烯丙基二硫抑制人角鲨烯单加氧酶,角鲨烯环氧化的IC50为400μM[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Gupta N, et al. Garlic and garlic-derived compounds inhibit human squalene monooxygenase. J Nutr. 2001;131(6):1662-1667.

二烯丙基二硫醚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
185.0±0.0 °C at 760 mmHg

[ 分子式 ]:
C₆H₁₀S₂

[ 分子量 ]:
146.274

[ 闪点 ]:
42.4±25.8 °C

[ 精确质量 ]:
146.022385

[ PSA ]:
50.60000

[ LogP ]:
3.26

[ 外观性状 ]:
透明黄色液体

[ 蒸汽密度 ]:
>5 (vs air)

[ 蒸汽压 ]:
1.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.534

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
水溶性：不溶

二烯丙基二硫醚MSDS

二烯丙基二硫醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BB1000000

CHEMICAL NAME :: Allyl disulfide

CAS REGISTRY NUMBER :: 2179-57-9

BEILSTEIN REFERENCE NO. :: 1699241

LAST UPDATED :: 199801

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H10-S2

MOLECULAR WEIGHT :: 146.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 878 mg/kg/6D-I

TOXIC EFFECTS :: Endocrine - other changes Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 10 mg/L

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,379,1997

二烯丙基二硫醚安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R10;R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S37/39-S16

[ 危险品运输编码 ]:
UN 2810 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
BB1000000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
3911900004

二烯丙基二硫醚合成路线

二烯丙基二硫醚上下游产品

二烯丙基二硫醚上游产品

二烯丙基二硫醚下游产品

二烯丙基二硫醚制备

由烯丙基硫醇与碘在乙醇和吡啶存在下氧化而得

二烯丙基二硫醚海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

二烯丙基二硫醚文献

Optimizations of packed sorbent and inlet temperature for large volume-direct aqueous injection-gas chromatography to determine high boiling volatile organic compounds in water.

J. Chromatogr. A. 1356 , 221-9, (2014)

For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromat...

Effect of processing conditions on the organosulfides of shallot (Allium cepa L. Aggregatum group).

J. Agric. Food Chem. 62(23) , 5296-304, (2014)

There is a growing account of the health benefits of H2S as an endogenous cell-signaling molecule. H2S from organic polysulfides, in particular, is increasingly gaining attention for their beneficial ...

The defense substance allicin from garlic permeabilizes membranes of Beta vulgaris, Rhoeo discolor, Chara corallina and artificial lipid bilayers.

Biochim. Biophys. Acta 1850(4) , 602-11, (2015)

Allicin (diallylthiosulfinate) is the major volatile- and antimicrobial substance produced by garlic cells upon wounding. We tested the hypothesis that allicin affects membrane function and investigat...

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