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1-甲基胍盐酸盐

1-甲基胍盐酸盐用途

1-甲基胍盐酸盐名称

[ CAS 号 ]:
21770-81-0

[ 中文名 ]:
1-甲基胍盐酸盐

[ 英文名 ]:
1-Methylguanidine hydrochloride

[中文别名 ]:

[英文别名 ]:

1-Methylguanidine hydrochloride
1-Methylguanidine HCl
2-methylguanidine hydrochloride
Methylguanidine HCl
Methylguanidinehydrochloride
MFCD00012576

1-甲基胍盐酸盐物理化学性质

[ 密度 ]:
1.22 g/mL at 20 °C(lit.)

[ 沸点 ]:
72 °C

[ 熔点 ]:
-20 °C

[ 分子式 ]:
C₂H₈ClN₃

[ 分子量 ]:
109.55800

[ 闪点 ]:
65 °F

[ 精确质量 ]:
109.04100

[ PSA ]:
61.90000

[ LogP ]:
1.09220

[ 外观性状 ]:
结晶

[ 折射率 ]:
n20/D 1.4279(lit.)

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
insoluble

1-甲基胍盐酸盐MSDS

详细MSDS(安全技术说明书)

1-甲基胍盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF3990000

CHEMICAL NAME :: Guanidine, 1-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 21770-81-0

LAST UPDATED :: 199009

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C2-H7-N3.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 28,251,1926

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 1,434,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04013

1-甲基胍盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319

[ 警示性声明 ]:
P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MF3990000

1-甲基胍盐酸盐制备

1-甲基胍盐酸盐文献

Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.

J. Pharm. Pharm. Sci. 17(4) , 475-84, (2015)

Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a majo...

Structure and dynamics of a salt-bridge model system in water and DMSO.

J. Chem. Phys. 142 , 212436, (2015)

We study the interaction between the ions methylguanidinium and trifluoroacetate dissolved in D2O and dimethylsulfoxide with linear infrared spectroscopy and femtosecond two-dimensional infrared spect...

In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells.

J. Pharm. Pharmacol. 67(2) , 170-7, (2015)

It has been reported that intestinal urate excretion is increased at chronic kidney disease (CKD) state. In this report, whether uremic toxins are involved in the upregulation of intestinal breast can...

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