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JS-K

JS-K用途

JS-K是一种NO供体,在生理pH下与谷胱甘肽反应生成NO[1]。JS-K抑制Jurkat T急性淋巴细胞白血病细胞的增殖、诱导凋亡并扰乱细胞周期[2]。

JS-K名称

[ CAS 号 ]:
205432-12-8

[ 英文名 ]:
JS-K

[英文别名 ]:

HMS3261L12
JS-K

JS-K生物活性

[ 描述 ]:

JS-K是一种NO供体,在生理pH下与谷胱甘肽反应生成NO[1]。JS-K抑制Jurkat T急性淋巴细胞白血病细胞的增殖、诱导凋亡并扰乱细胞周期[2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

[参考文献]

[1]. Shami PJ, et al. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity. Mol Cancer Ther. 2003 Apr;2(4):409-17.

JS-K物理化学性质

[ 密度 ]:
1.606g/cm3

[ 沸点 ]:
546.692ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₁₆N₆O₈

[ 分子量 ]:
384.30200

[ 闪点 ]:
284.429ºC

[ 精确质量 ]:
384.10300

[ PSA ]:
174.76000

[ LogP ]:
2.89380

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.656

[ 储存条件 ]:
-20°C，密闭，干燥

JS-KMSDS

详细MSDS(安全技术说明书)

JS-K安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TL1364200

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JS-K上游产品

JS-K下游产品

JS-K文献

N-(2-Hydroxypropyl)methacrylamide Copolymer-Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia.

Macromol. Biosci. 16 , 121-8, (2016)

There is a need for new treatment strategies of acute myeloid leukemia (AML). In this study, four different drugs, including cytarabine, daunorubicin, GDC-0980, and JS-K, were investigated in vitro fo...

Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance.

Redox Biol. 1 , 115-24, (2013)

JS-K is a nitric oxide (NO)-releasing prodrug of the O (2)-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in...

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells.

BMC Cancer 12 , 130, (2012)

Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In conseq...

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