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羟苯磺酸钙

羟苯磺酸钙用途

羟苯磺酸钙为改善微循环新药原料；有降血糖、抑制血小板聚集、降低毛细血管通透性等药理作用，特别对糖尿病导致的视网膜病变等疾病有明显的抑制作用和转递作用。

羟苯磺酸钙名称

[ CAS 号 ]:
20123-80-2

[ 中文名 ]:
2,5-二羟基苯磺酸钙

[ 英文名 ]:
Calcium dobesilate

[中文别名 ]:

羟苯磺酸钙

[英文别名 ]:

calcium 2,5-dihydroxybenzenesulfonate
Calcium dobesilate
Nugatex
Dobesilat-Calciumsalz
Dobesilato calcico
Calcium Doxybensylate
calcium salt of 2,5-dihydroxybenzenesulfonic acid
Doxium
Calcii dobesilas
MFCD08457542

羟苯磺酸钙生物活性

[ 描述 ]:

Calcium dobesilate 是一种血管保护剂,在许多国家广泛用于慢性静脉疾病、糖尿病视网膜病变以及痔疮发作等治疗。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Allain H, et al. Safety of calcium dobesilate in chronic venous disease, diabetic retinopathy and haemorrhoids. Drug Saf. 2004;27(9):649-60.

羟苯磺酸钙物理化学性质

[ 分子式 ]:
C₁₂H₁₀CaO₁₀S₂

[ 分子量 ]:
418.410

[ 精确质量 ]:
417.934143

[ PSA ]:
212.08000

[ LogP ]:
2.16540

[ 储存条件 ]:
room temp

羟苯磺酸钙MSDS

详细MSDS(安全技术说明书)

羟苯磺酸钙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB6127000

CHEMICAL NAME :: Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt

CAS REGISTRY NUMBER :: 20123-80-2

LAST UPDATED :: 199512

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H10-O10-S2.Ca

MOLECULAR WEIGHT :: 418.42

WISWESSER LINE NOTATION :: WSO&R BQ EQ 2 &-CA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7061 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7549 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 876 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 775 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 30,415,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3509207

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4979 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (1),29,1994

羟苯磺酸钙安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26

[ 海关编码 ]:
2924299090

羟苯磺酸钙海关

[ 海关编码 ]: 2908999090

[ 中文概述 ]:
2908999090 其他酚及酚醇的卤化等衍生物（包括其磺化、硝化或亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%