2,2-联苯基-1-苦基肼基

2,2-联苯基-1-苦基肼基用途

DPPH (2,2-Diphenyl-1-picrylhydrazyl) 是一种稳定的自由基,可用于测量抗氧化剂的自由基清除活性。DPPH 中氮原子的奇数电子通过从抗氧化剂吸收氢原子而还原为相应的肼。DPPH 方法可用于水性和非极性有机溶剂中,并可用于检查亲水性和亲脂性抗氧化剂。

2,2-联苯基-1-苦基肼基名称

[ CAS 号 ]:
1898-66-4

[ 中文名 ]:
1,1-二苯-2-苦基肼

[ 英文名 ]:
DPPH

[中文别名 ]:

[英文别名 ]:

DPPH radical
diphenylpicrylhydrazylfreeradical
2,2-Diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl
DPPH
di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium
1,1-Diphenyl-2-picrylhydrazyl Free Radical
2,2-Diphenyl-1-(2,4,6-trinitrophenyl)hydrazino
Hydrazinyl, 2,2-diphenyl-1-(2,4,6-trinitrophenyl)-
Diphenylpicrylhydrazyl.
1,1-Diphenyl-2-picrylhydrazyl radical

2,2-联苯基-1-苦基肼基生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

DPPH由于其奇数电子而在517nm处显示出强吸收带,并且溶液呈现深紫色,当电子对断开时吸收消失。得到的脱色相对于吸收的电子数是化学计量的。0.5 mM的酒精溶液颜色密集,在此浓度下,在有用的吸收范围内遵守Lambert-Beer定律[1]。DPPH测定是一种快速,简单,廉价且广泛使用的方法,用于测量化合物作为自由基清除剂或氢供体的能力,并评估食物的抗氧化活性。它还可用于量化复杂生物系统中的抗氧化剂,固体或液体样品。该方法简便,适用于测定果汁和蔬菜汁的总抗氧化能力和自由基清除活性。该试验已成功用于研究小麦籽粒和麸皮,蔬菜,共轭亚油酸,草药,食用种子油和面粉在几种不同溶剂体系中的抗氧化性能,包括乙醇,丙酮水溶液,甲醇,乙醇水溶液和苯。它是一种方便的方法,用于橄榄油,水果,果汁和葡萄酒中半胱氨酸,谷胱甘肽,抗坏血酸,生育酚和多羟基芳香族化合物的抗氧化测定[1]。

[参考文献]

[1]. Kedare SB, et al. Genesis and development of DPPH method of antioxidant assay. J Food Sci Technol. 2011 Aug;48(4):412-22.

2,2-联苯基-1-苦基肼基物理化学性质

[ 熔点 ]:
136-138ºC

[ 分子式 ]:
C₁₈H₁₂N₅O₆

[ 分子量 ]:
394.318

[ 精确质量 ]:
394.078766

[ PSA ]:
140.70000

[ LogP ]:
5.97000

[ 外观性状 ]:
green

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Soluble in dimethyl formamide, ethanol, chloroform, ether, carbon disulfinde, acetone, oils, carbon tetrachloride, glacial acetic acid and toluene. Insoluble in water.

2,2-联苯基-1-苦基肼基MSDS

详细MSDS(安全技术说明书)

2,2-联苯基-1-苦基肼基毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW3250000

CHEMICAL NAME :: Hydrazyl, 2,2-diphenyl-1-(2,4,6-trinitrophenyl)-

CAS REGISTRY NUMBER :: 1898-66-4

BEILSTEIN REFERENCE NO. :: 1846081

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H12-N5-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06207

2,2-联苯基-1-苦基肼基安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN2811

[ WGK德国 ]:
1

[ RTECS号 ]:
MW3250000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

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