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4-氯苯乙酸

4-氯苯乙酸用途

4-Chlorophenylacetic acid 是一种小芳香族脂肪酸家族的化合物,具有抗癌特性的。4-Chlorophenylacetic acid 可为假单胞菌提供碳和能量。

4-氯苯乙酸名称

[ CAS 号 ]:
1878-66-6

[ 中文名 ]:
对氯苯乙酸

[ 英文名 ]:
4-Chlorophenylacetic acid

[中文别名 ]:

[英文别名 ]:

EINECS 217-521-6
Acetic acid, 4-chlorophenyl-
(4-Chlorophenyl)acetic acid
4-Chlorobenzeneacetic acid
4-Chlorophenylacetic acid
2-(4-chloro-phenyl)-acetic acid
p-chlorophenylacetate
Acetic acid,(p-chlorophenyl)
4-Cl-phenylacetic acid
p-chlorophenyl acetic acid

4-氯苯乙酸生物活性

[ 描述 ]:

4-Chlorophenylacetic acid 是一种小芳香族脂肪酸家族的化合物,具有抗癌特性的。4-Chlorophenylacetic acid 可为假单胞菌提供碳和能量。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. U Klages, et al. Degradation of 4-chlorophenylacetic Acid by a Pseudomonas Species. J Bacteriol. 1981 Apr;146(1):64-8.

[2]. Neil Sidell, et al. Inhibition of Estrogen-Induced Mammary Tumor Formation in MMTV-aromatase Transgenic Mice by 4-chlorophenylacetate. Cancer Lett. 2007 Jun 28;251(2):302-10.

4-氯苯乙酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
294.1±15.0 °C at 760 mmHg

[ 熔点 ]:
102-105 °C(lit.)

[ 分子式 ]:
C₈H₇ClO₂

[ 分子量 ]:
170.593

[ 闪点 ]:
131.7±20.4 °C

[ 精确质量 ]:
170.013458

[ PSA ]:
37.30000

[ LogP ]:
2.10

[ 外观性状 ]:
白色至奶油色色的粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.570

[ 储存条件 ]:
室温

4-氯苯乙酸MSDS

4-氯苯乙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG0590000

CHEMICAL NAME :: Acetic acid, (p-chlorophenyl)-

CAS REGISTRY NUMBER :: 1878-66-6

BEILSTEIN REFERENCE NO. :: 1072816

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H7-Cl-O2

MOLECULAR WEIGHT :: 170.60

WISWESSER LINE NOTATION :: QV1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,286,1958

4-氯苯乙酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H312 + H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R20/21

[ 安全声明 (欧洲) ]:
S36/37-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AG0590000

[ 海关编码 ]:
2916340090

4-氯苯乙酸合成路线

4-氯苯乙酸上下游产品

4-氯苯乙酸上游产品

4-氯苯乙酸下游产品

4-氯苯乙酸海关

[ 海关编码 ]: 2916399090

[ 中文概述 ]:
2916399090 其他芳香一元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

4-氯苯乙酸文献

Novel Chryseobacterium sp. PYR2 degrades various organochlorine pesticides (OCPs) and achieves enhancing removal and complete degradation of DDT in highly contaminated soil.

J. Environ. Manage. 161 , 350-7, (2015)

Long term residues of organochlorine pesticides (OCPs) in soils are of great concerning because they seriously threaten food security and human health. This article focuses on isolation of OCP-degradi...

Degradation of 4-chlorophenylacetic acid by a Pseudomonas species.

J. Bacteriol. 146(1) , 64-8, (1981)

Pseudomonas sp. strain CBS3 was able to utilize 4-chlorophenylacetic acid as the sole source of carbon and energy. When this strain was grown with 4-chlorophenylacetic acid, homoprotocatechuic acid wa...

Inhibition of estrogen-induced mammary tumor formation in MMTV-aromatase transgenic mice by 4-chlorophenylacetate.

Cancer Lett. 251(2) , 302-10, (2007)

Treatment of estrogen-sensitive breast cancer with selective estrogen selective modulators (SERMs) and, more recently, aromatase inhibitors has met with wide success. However, antagonism of estrogen r...

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