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2-(N-7-硝基-2,1,3-苯并恶二唑-4-氨基)-2-脱氧-D-葡萄糖

用途

2-NBDG是测量葡萄糖摄取的荧光指标,也是细胞活力的指标。

名称

[ CAS 号 ]:
186689-07-6

[ 中文名 ]:
2-(N-7-硝基-2,1,3-苯并恶二唑-4-氨基)-2-脱氧-D-葡萄糖

[ 英文名 ]:
2-NBDG

[中文别名 ]:

[英文别名 ]:

生物活性

[ 描述 ]:

2-NBDG是测量葡萄糖摄取的荧光指标,也是细胞活力的指标。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

染料试剂

研究领域 >> 其他

[参考文献]

[1]. Zou C, et al. 2-NBDG as a fluorescent indicator for direct glucose uptake measurement. J Biochem Biophys Methods. 2005 Sep 30;64(3):207-15.

[相关活性小分子]

物理化学性质

[ 密度 ]:
1.750±0.06 g/cm3

[ 沸点 ]:
707.6±70.0 °C at 760 mmHg

[ 分子式 ]:
C₁₂H₁₄N₄O₈

[ 分子量 ]:
342.262

[ 闪点 ]:
381.7±35.7 °C

[ 精确质量 ]:
342.081177

[ PSA ]:
186.92000

[ LogP ]:
-0.41

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.770

[ 储存条件 ]:
2-8℃

[ 水溶解性 ]:
Very slightly soluble (0.48 g/L) (25 ºC)

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

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Biomaterials 51 , 1-11, (2015)

Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer c...

Preconditioning L6 Muscle Cells with Naringin Ameliorates Oxidative Stress and Increases Glucose Uptake.

PLoS ONE 10 , e0132429, (2015)

Enhanced oxidative stress contributes to pathological changes in diabetes and its complications. Thus, strategies to reduce oxidative stress may alleviate these pathogenic processes. Herein, we have i...

Redox-based probes as tools to monitor oxidized protein tyrosine phosphatases in living cells.

Eur. J. Med. Chem. 88 , 28-33, (2014)

Reversible oxidation of protein tyrosine phosphatases (PTPs) has emerged as an important regulatory mechanism whereby reactive oxygen species (ROS) inactivates the PTP and promotes phosphorylation and...

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