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6-羟基华法林

6-羟基华法林名称

[ CAS 号 ]:
17834-02-5

[ 中文名 ]:
6-羟基华法林

[ 英文名 ]:
6-hydroxy Warfarin

[中文别名 ]:

[英文别名 ]:

6-Hydroxywarfarin
4,6-dihydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one

6-羟基华法林物理化学性质

[ 密度 ]:
1.384 g/cm3

[ 沸点 ]:
540.2ºC at 760 mmHg

[ 熔点 ]:
119-120ºC

[ 分子式 ]:
C₁₉H₁₆O₅

[ 分子量 ]:
324.32700

[ 闪点 ]:
197.7ºC

[ 精确质量 ]:
324.10000

[ PSA ]:
87.74000

[ LogP ]:
3.31520

[ 外观性状 ]:
淡棕色固体

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.659

6-羟基华法林MSDS

6-羟基华法林安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932209090

6-羟基华法林合成路线

6-羟基华法林上下游产品

6-羟基华法林上游产品

6-羟基华法林下游产品

6-羟基华法林海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-羟基华法林文献

Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers.

J. Chromatogr. A. 1363 , 200-6, (2014)

Several offline and online 2D HPLC methods were investigated for the reversed phase resolution of a complex mixture of closely related warfarin and hydroxywarfarin isomers. By combining reversed phase...

Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.

Chem. Res. Toxicol. 23(5) , 939-45, (2010)

Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how meta...

Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins.

Drug Metab. Lett. 6(3) , 157-64, (2012)

Coumadin (R/S-warfarin) is a highly efficacious and widely used anticoagulant; however, its highly variable metabolism remains an important contributor to uncertainties in therapeutic responses. Pharm...

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