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佛波醇

佛波醇用途

Phorbol 是一种具有毒性的二萜类化合物，它的酯类具有很高的生物活性。

佛波醇名称

[ CAS 号 ]:
17673-25-5

[ 中文名 ]:
佛波醇

[ 英文名 ]:
phorbol

[英文别名 ]:

Phorbol,Pentahydroxy-tigliadienon
MFCD00065450
4b,9a,12b,13a,20-pentahydroxytiglia-1,6-dien-3-one
Phorbol-(3)
4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-et
PHORBOL

佛波醇生物活性

[ 描述 ]:

Phorbol 是一种具有毒性的二萜类化合物,它的酯类具有很高的生物活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 萜类化合物和糖苷

研究领域 >> 癌症

[参考文献]

[1]. Matsuzawa Y, et al. Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf. J Pharmacol Sci. 2009 Oct;111(2):182-92

[相关活性小分子]

佛波醇物理化学性质

[ 密度 ]:
1.415 g/cm3

[ 沸点 ]:
572ºC at 760 mmHg

[ 熔点 ]:
250-251ºC DECOMP

[ 分子式 ]:
C₂₀H₂₈O₆

[ 分子量 ]:
364.43300

[ 闪点 ]:
313.8ºC

[ 精确质量 ]:
364.18900

[ PSA ]:
118.22000

[ 蒸汽压 ]:
1.83E-15mmHg at 25°C

[ 折射率 ]:
1.648

[ 储存条件 ]:
-20°C

佛波醇MSDS

详细MSDS(安全技术说明书)

佛波醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ0600000

CHEMICAL NAME :: 5H-Cyclopropa(3,4)benz(1,2-e)azulen-5-one, 1,1a-beta,1b-alpha,4,4a,7a-beta,7b,8,9,9a- decahydro-4a-alpha,7b-alpha,9-beta,9a-alpha-tetrahydr oxy-3-(hydroxymethyl) -1,1,6,8-alpha- tetramethyl-

CAS REGISTRY NUMBER :: 17673-25-5

LAST UPDATED :: 199304

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C20-H28-O6

MOLECULAR WEIGHT :: 364.48

WISWESSER LINE NOTATION :: L E3 B675 MV IU NUTJ BQ C1 DQ EQ F1 F1 JO1 LQ N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 22,241,1972 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg/25W

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 30,2744,1970

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 284 mg/kg/39W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

REFERENCE :: JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979- Volume(issue)/page/year: 95,19,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 64 mg/kg

SEX/DURATION :: lactating female 2 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 165,394,1980 *** REVIEWS *** TOXICOLOGY REVIEW CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,1171,1976

佛波醇安全信息

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
26-27-36/37/39-45-28

[ 危险品运输编码 ]:
UN 2811 6

[ WGK德国 ]:
3

[ RTECS号 ]:
GZ0600000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

佛波醇

佛波醇用途

佛波醇名称

佛波醇生物活性

佛波醇物理化学性质

佛波醇MSDS

详细MSDS(安全技术说明书)

佛波醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

佛波醇安全信息

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