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2-氨基-6-甲氧基苯骈噻唑

2-氨基-6-甲氧基苯骈噻唑用途

染料中间体。用于制造阳离子艳蓝RL、阳离子黄2RL；由它制备6-甲氧基-3-甲基苯并噻唑腙，进而生产阳离子黄GL等。

2-氨基-6-甲氧基苯骈噻唑名称

[ CAS 号 ]:
1747-60-0

[ 中文名 ]:
2-氨基-6-甲氧基苯并噻唑

[ 英文名 ]:
2-Amino-6-methoxybenzothiazole

[中文别名 ]:

[英文别名 ]:

2-Amino-6-methoxybenzothiazole
6-Methoxy-1,3-benzothiazol-2-amine
6-Methoxy-2-aminobenzothiazole
2-Benzothiazolamine, 6-methoxy-
EINECS 217-130-0
MFCD00005787

2-氨基-6-甲氧基苯骈噻唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
347.5±34.0 °C at 760 mmHg

[ 熔点 ]:
165-167 °C(lit.)

[ 分子式 ]:
C₈H₈N₂OS

[ 分子量 ]:
180.227

[ 闪点 ]:
163.9±25.7 °C

[ 精确质量 ]:
180.035736

[ PSA ]:
76.38000

[ LogP ]:
1.81

[ 外观性状 ]:
淡黄褐色的粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.705

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
<0.1 g/100 mL at 21 ºC

2-氨基-6-甲氧基苯骈噻唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL2100000

CHEMICAL NAME :: Benzothiazole, 2-amino-6-methoxy-

CAS REGISTRY NUMBER :: 1747-60-0

BEILSTEIN REFERENCE NO. :: 0131202

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H8-N2-O-S

MOLECULAR WEIGHT :: 180.24

WISWESSER LINE NOTATION :: T56 BN DSJ CZ GO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 10 umol/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981

2-氨基-6-甲氧基苯骈噻唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
DL2100000

[ 海关编码 ]:
2934999090

2-氨基-6-甲氧基苯骈噻唑合成路线

详细合成路线

2-氨基-6-甲氧基苯骈噻唑上下游产品

2-氨基-6-甲氧基苯骈噻唑上游产品

2-氨基-6-甲氧基苯骈噻唑下游产品

2-氨基-6-甲氧基苯骈噻唑制备

先由对氨基苯甲醚盐酸盐和硫氰酸钠反应，得到对甲氧基苯基硫脲，再与氯化硫闭环而得。工艺过程如下：（1）在搪玻璃锅中加入水，加热到60℃，搅拌下慢慢加入对氨基苯甲醚，在60-65℃搅拌30min使其完全溶解。用30%工业盐酸调整溶液酸度刚果红试纸呈微蓝色，维持10min，再加硫氰酸钠，加热，慢慢升温到105℃，在105℃左右回流24h。然后冷到25℃过滤。滤饼用水洗涤、干燥，得对甲氧基苯基硫脲。（2）将无水氯仿吸入干燥的搪玻璃锅中，搅拌下加入干燥的对甲氧基苯硫脲。加热到60-62℃，蒸出部分氯仿及原料中的水。然后冷却到25℃，逐渐加入氯化硫。加完后，在30℃搅拌1h，升温到43-45℃反应4h。反应中产生氯化氢气体，通过吸收系统吸收。再于62-64℃回流反应10h。然后冷却到60℃以下，将物料压到装有烟囱灰（代活性炭）和水的酸性蒸馏锅中，用直接蒸汽蒸馏回收氯仿，直到温度95℃，并维持15min。氯仿回收后停止蒸馏，冷到90℃，加水调整体积，再加冰冷却到45℃，细流加入30%液碱，调整pH值至4-5，搅拌15min。抽滤，将滤液加热到60℃，用30%液碱进行碱析酚酞呈微红色。抽滤，所得滤饼即为成品。熔点160-163℃收率85%。

2-氨基-6-甲氧基苯骈噻唑海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-氨基-6-甲氧基苯骈噻唑文献

Synthesis and antimicrobial activity of new 4-thiazolidinone derivatives containing 2-amino-6-methoxybenzothiazole.

Saudi Pharm. J. 18(3) , 129-36, (2010)

A novel series of Schiff bases 5a-j and 4-thiazolidinones 6a-j have been prepared from the building blocks 2-chloro pyridine-3-carboxylic acid [1] and 2-amino-6-methoxy-benzothiazole [2]. All of the s...

Effect of Aroclor 1254 dose upon S9 activation of aromatic amine bacterial mutagens.

Mutat. Res. 77(4) , 361-6, (1980)

Structural, vibrational, electronic investigations and quantum chemical studies of 2-amino-4-methoxybenzothiazole.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 102 , 327-40, (2013)

Extensive vibrational investigations of 2-amino-4-methoxybenzothiazole have been carried out with FTIR and FT-Raman spectral techniques. The electronic structure of the molecule has been analysed by U...

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