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獐牙菜苦苷

獐牙菜苦苷用途

Swertiamarin 是一种在 Enicostemma Species 属植物中发现的裂环烯醚萜苷,具有降血糖和降血脂的作用。

獐牙菜苦苷名称

[ CAS 号 ]:
17388-39-5

[ 中文名 ]:
獐牙菜苦甙

[ 英文名 ]:
Swertiamarin

[中文别名 ]:

[英文别名 ]:

MFCD07783984
Swertiamarin

獐牙菜苦苷生物活性

[ 描述 ]:

Swertiamarin 是一种在 Enicostemma Species 属植物中发现的裂环烯醚萜苷,具有降血糖和降血脂的作用。

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. Patel N, et al. Curr Drug Targets. 2018;19(16):1958-1967. doi: 10.2174/1389450119666180406113428.

獐牙菜苦苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
649.3±55.0 °C at 760 mmHg

[ 熔点 ]:
111ºC

[ 分子式 ]:
C₁₆H₂₂O₁₀

[ 分子量 ]:
374.340

[ 闪点 ]:
237.7±25.0 °C

[ 精确质量 ]:
374.121307

[ PSA ]:
155.14000

[ LogP ]:
-3.15

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±4.4 mmHg at 25°C

[ 折射率 ]:
1.626

[ 储存条件 ]:
?20°C

獐牙菜苦苷MSDS

详细MSDS(安全技术说明书)

獐牙菜苦苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ1366700

CHEMICAL NAME :: 1H,3H-Pyrano(3,4-c)pyran-1-one, 4,4a,5,6-tetrahydro-5-ethenyl-6-(beta-d-glucopyranosy loxy)-4a-hydroxy-, (4aR-(4a-alpha,5-beta,6-alpha))-

CAS REGISTRY NUMBER :: 17388-39-5

BEILSTEIN REFERENCE NO. :: 0055278

LAST UPDATED :: 199806

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H22-O10

MOLECULAR WEIGHT :: 374.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,464,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,464,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,464,1982

獐牙菜苦苷安全信息

[ 危害码 (欧洲) ]:
C

[ 风险声明 (欧洲) ]:
R23:Toxic by inhalation. R34:Causes burns.

[ 安全声明 (欧洲) ]:
S26-S36-S45

[ 危险品运输编码 ]:
UN 1789

[ WGK德国 ]:
3.0

[ RTECS号 ]:
UQ1366700

[ 包装等级 ]:
III

[ 危险类别 ]:
8

獐牙菜苦苷文献

Development and validation of a LC-ESI-MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(19) , 1653-8, (2011)

A new LC-ESI-MS/MS assay method has been developed and validated for the quantification of swertiamarin, a representative bioactive substance of Swertia plants, in rat plasma using gentiopicroside, an...

Hypoglycemic activity of C-glycosyl flavonoid from Enicostemma hyssopifolium.

Pharm. Biol. 49(4) , 383-91, (2011)

Enicostemma hyssopifolium Verdoon (Gentianaceae) has been documented for various therapeutic effects in traditional systems of medicine; the hypoglycemic and hypolipidemic activities are also well rep...

Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats.

J. Nat. Med. 63(4) , 437-42, (2009)

We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats...

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