6-甲基屈

6-甲基屈名称

[ CAS 号 ]:
1705-85-7

[ 中文名 ]:
6-甲基屈

[ 英文名 ]:
6-Methylchrysene

[英文别名 ]:

Chrysene, 6-methyl-
6-Methylchrysene

6-甲基屈物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
449.4±12.0 °C at 760 mmHg

[ 熔点 ]:
161.5°C

[ 分子式 ]:
C₁₉H₁₄

[ 分子量 ]:
242.314

[ 闪点 ]:
217.8±13.7 °C

[ 精确质量 ]:
242.109543

[ LogP ]:
6.37

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.748

[ 储存条件 ]:
2-8°C

6-甲基屈MSDS

6-甲基屈毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GC1750000

CHEMICAL NAME :: Chrysene, 6-methyl-

CAS REGISTRY NUMBER :: 1705-85-7

BEILSTEIN REFERENCE NO. :: 1954732

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C19-H14

MOLECULAR WEIGHT :: 242.33

WISWESSER LINE NOTATION :: L E6 B666J D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg/3W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg/40W

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 36,4525,1976 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,379,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,379,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

6-甲基屈安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H410

[ 警示性声明 ]:
P273-P501

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-50

[ 安全声明 (欧洲) ]:
61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ 海关编码 ]:
2902909090

6-甲基屈合成路线

6-甲基屈上下游产品

6-甲基屈上游产品

6-甲基屈下游产品

6-甲基屈海关

[ 海关编码 ]: 2902909090

[ 中文概述 ]:
2902909090. 其他芳香烃. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:2.0%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

6-甲基屈文献

Metabolism of chrysene, 5-methylchrysene, 6-methylchrysene and 5,6-dimethylchrysene in rat liver cytosol, in vitro, and in rat subcutaneous tissue, in vivo.

Chem. Biol. Interact. 77(2) , 203-21, (1991)

The polynuclear aromatic hydrocarbon chrysene undergoes a bioalkylation substitution reaction in vitro, in rat liver cytosol preparations, and in vivo, in rat dorsal subcutaneous tissue to yield 6-met...

Enhancing effect of a bay region methyl group on tumorigenicity in newborn mice and mouse skin of enantiomeric bay region diol epoxides formed stereoselectively from methylchrysenes in mouse epidermis.

Cancer Res. 47(20) , 5310-5, (1987)

The stereochemistry of diol epoxide formation in mouse epidermis upon topical application of [3H]-1R,2R-dihydroxy-1,2-dihydro-5-methylchrysene ([3H]-5-MeC-1R,2R-diol) and [3H]-6-MeC-1R,2R-diol, and th...

Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells.

Toxicology 247(2-3) , 93-101, (2008)

Methylated chrysenes (MeChry) are important cigarette smoke constituents and 5-MeChry has been listed as possibly carcinogenic to humans. Although a major attention has been in past paid especially to...

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