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4,7-二苯基-1,10-菲咯啉

4,7-二苯基-1,10-菲咯啉用途

红菲绕啉是可用于通过染色法测量水,血清和尿液样中铁浓度的试剂。

4,7-二苯基-1,10-菲咯啉名称

[ CAS 号 ]:
1662-01-7

[ 中文名 ]:
4,7-二苯基-1,10-菲罗啉

[ 英文名 ]:
Bathophenanthroline

[中文别名 ]:

[英文别名 ]:

4,7-diphenyl[1,10]phenanthroline
bathophenanthrolin
4,4'-diphenyl-1,10-phenantrolene
4,7-Diphenyl-1,10-phenanthroline
1,10-Phenanthroline, 4,7-diphenyl-
Bathophen
4,7-Diphenyl-1,10-phenanthroline,BPhen
BATHOPHENANTHROLINE R. G.
1,10-bathophenanthroline
MFCD00004976

4,7-二苯基-1,10-菲咯啉生物活性

[ 描述 ]:

红菲绕啉是可用于通过染色法测量水,血清和尿液样中铁浓度的试剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

染料试剂

[相关活性小分子]

4,7-二苯基-1,10-菲咯啉物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
543.1±50.0 °C at 760 mmHg

[ 熔点 ]:
218-220 °C(lit.)

[ 分子式 ]:
C₂₄H₁₆N₂

[ 分子量 ]:
332.397

[ 闪点 ]:
242.1±21.4 °C

[ 精确质量 ]:
332.131348

[ PSA ]:
25.78000

[ LogP ]:
5.51

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.710

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：微溶；可溶于：苯,乙醇,丙酮

4,7-二苯基-1,10-菲咯啉MSDS

4,7-二苯基-1,10-菲咯啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF8427000

CHEMICAL NAME :: 1,10-Phenanthroline, 4,7-diphenyl-

CAS REGISTRY NUMBER :: 1662-01-7

BEILSTEIN REFERENCE NO. :: 0261048

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C24-H16-N2

MOLECULAR WEIGHT :: 332.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 440 ug/L

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,1209,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0594 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 700 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0594 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 249 (estimated) No. of Female Employees: 171 (estimated)

4,7-二苯基-1,10-菲咯啉安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SF8427000

[ 海关编码 ]:
29339990

4,7-二苯基-1,10-菲咯啉合成路线

4,7-二苯基-1,10-菲咯啉上下游产品

4,7-二苯基-1,10-菲咯啉上游产品

4,7-二苯基-1,10-菲咯啉下游产品

4,7-二苯基-1,10-菲咯啉制备

1.在搅拌下将邻硝基苯胺和适量砷酸加到热的稀硫酸中，并加热至110℃时缓慢加入β -氯代苯丙酮，控制加入速度，使温度不超过140℃，加完后保温4h。然后倒入水中，加入氢氧化钠溶液中和，过滤后晾干沉淀，用苯萃取三次，蒸发回收苯后冷却至50～60℃，得粗品4-苯基-8-硝基喹啉，用丙酮洗粗品三次。再将洗涤后的产物与乙醇混合，搅拌下加入氯化亚锡，加热回流3h进行还原，静置后滤出橙色4-苯基-8- 氨基喹啉的复盐，用少量乙醇洗涤之后，加水调成糊状，加入氢氧化钠至强碱性，冷却后过
滤，结晶经水洗数次后于100℃烘干，再用苯萃取，蒸发回收苯，再用丙酮洗涤至橙色，即得还原产物4-苯基-8氨基喹啉。还原产物与水、硫酸、砷酸混合，加热至110℃时慢慢加入β  氯代苯丙酮，控制温度不超过140℃，加完后保温3h，然后加入大量水中，析出的结晶用稀硫酸洗涤，再用氨水中和，沉淀用水洗至中性，用苯萃取，用丙酮洗涤，最后用氯仿溶解脱色，再经丙酮洗涤后得成品。过程反应式为：

4,7-二苯基-1,10-菲咯啉海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4,7-二苯基-1,10-菲咯啉文献

Alterations of protein expression in conditions of copper-deprivation for Paracoccidioides lutzii in the presence of extracellular matrix components.

BMC Microbiol. 14 , 302, (2015)

Paracoccidioides spp is a fungi genus and the agent of paracoccidioidomycosis. The strategies of infection used by these pathogens involve the expression of proteins related to adaptation to the host,...

Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro.

J. Photochem. Photobiol. B, Biol. 138 , 124-33, (2014)

Ultraviolet B (UVB) irradiation may cause oxidative stress- and inflammation-dependent skin cancer and premature aging. Pyrrolidine dithiocarbamate (PDTC) is an antioxidant and inhibits nuclear factor...

Oxidative phosphorylation in Debaryomyces hansenii: physiological uncoupling at different growth phases.

Biochimie 102 , 124-36, (2014)

Physiological uncoupling of mitochondrial oxidative phosphorylation (OxPhos) was studied in Debaryomyces hansenii. In other species, such as Yarrowia lipolytica and Saccharomyces cerevisiae, OxPhos ca...

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