碘西他酸

碘西他酸用途

胆盐水(DRC 1201)是一种诊断辅助剂,是一种口服活性造影剂[1]。

碘西他酸名称

[ CAS 号 ]:
16034-77-8

[ 中文名 ]:
碘西他酸

[ 英文名 ]:
iocetamic acid (200 mg)

[中文别名 ]:

[英文别名 ]:

碘西他酸生物活性

[ 描述 ]:

胆盐水(DRC 1201)是一种诊断辅助剂,是一种口服活性造影剂[1]。

[ 相关类别 ]:

研究领域 >> 其他
信号通路 >> 其他 >> 其他

[体内研究]

胆盐水在大鼠中 LD50型为 7克/千克(口服) 和 0.7克/千克(静脉注射)[2].

[参考文献]

[1]. Owen JP, et al. Comparative study of iocetamic acid and calcium ipodate in the visualisation of the gallbladder and common bile duct. Clin Radiol. 1978 Sep;29(5):535-40.  

[2]. Janbroers JM, et al. Toxicologic studies of iocetamic acid in rats and dogs. Toxicol Appl Pharmacol. 1969 Mar;14(2):242-8.  

碘西他酸物理化学性质

[ 密度 ]:
2.416g/cm3

[ 沸点 ]:
658.2ºC at 760 mmHg

[ 熔点 ]:
224-225ºC

[ 分子式 ]:
C12H13I3N2O3

[ 分子量 ]:
613.95700

[ 闪点 ]:
351.9ºC

[ 精确质量 ]:
613.80600

[ PSA ]:
83.63000

[ LogP ]:
3.73740

[ 蒸汽压 ]:
3.21E-18mmHg at 25°C

[ 折射率 ]:
1.75

碘西他酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UE6050000
CHEMICAL NAME :
Propionic acid, 3-(acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methy l-
CAS REGISTRY NUMBER :
16034-77-8
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H13-I3-N2-O3
MOLECULAR WEIGHT :
613.97
WISWESSER LINE NOTATION :
ZR BI DI FI CNV1&1Y1&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,232,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,232,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,997,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6131 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 260 (estimated) No. of Female Employees: 140 (estimated)

碘西他酸安全信息

[ 海关编码 ]:
2924299090

碘西他酸海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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相关化合物

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