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L-蛋氨酸磺酸盐

L-蛋氨酸磺酸盐用途

L-蛋氨酸-DL-亚砜肟(MSX)是谷氨酰胺合成酶的抑制剂。L-蛋氨酸-DL-亚砜肟也是一种强效惊厥剂,主要影响星形胶质细胞的代谢和形态学。

L-蛋氨酸磺酸盐名称

[ CAS 号 ]:
15985-39-4

[ 中文名 ]:
L-蛋氨酸亚砜亚胺

[ 英文名 ]:
L-Methionine-DL-sulfoximine

[中文别名 ]:

[英文别名 ]:

L-S-(3-Amino-3-carboxypropyl)-S-methylsulfoximine
2-Amino-4-(S-methylsulfonimidoyl)butanoic acid
MFCD00002621
UNII:M9P6YZ6JX9
L-Methionine sulfoximine

L-蛋氨酸磺酸盐生物活性

[ 描述 ]:

L-蛋氨酸-DL-亚砜肟(MSX)是谷氨酰胺合成酶的抑制剂。L-蛋氨酸-DL-亚砜肟也是一种强效惊厥剂,主要影响星形胶质细胞的代谢和形态学。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Albrecht J, Norenberg MD. L-methionine-DL-sulfoximine induces massive efflux of glutamine from cortical astrocytes in primary culture. Eur J Pharmacol. 1990;182(3):587-589.

[2]. Premakumar R, Sorger GJ, Gooden D. Repression of nitrate reductase in Neurospora studied by using L-methionine-DL-sulfoximine and glutamine auxotroph gln-1b. J Bacteriol. 1980;143(1):411-415.

L-蛋氨酸磺酸盐物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
352.2±52.0 °C at 760 mmHg

[ 熔点 ]:
>210ºC (dec.)(lit.)

[ 分子式 ]:
C₅H₁₂N₂O₃S

[ 分子量 ]:
180.225

[ 闪点 ]:
166.8±30.7 °C

[ 精确质量 ]:
180.056870

[ PSA ]:
112.62000

[ LogP ]:
-1.38

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.560

[ 储存条件 ]:
0-6°C

[ 稳定性 ]:
Temperature Sensitive

L-蛋氨酸磺酸盐MSDS

详细MSDS(安全技术说明书)

L-蛋氨酸磺酸盐安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925290090

L-蛋氨酸磺酸盐上下游产品

L-蛋氨酸磺酸盐上游产品

L-蛋氨酸磺酸盐下游产品

L-蛋氨酸磺酸盐海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

L-蛋氨酸磺酸盐文献

Notch ligand delta-like1: X-ray crystal structure and binding affinity.

Biochem. J. 468 , 159-66, (2015)

The Notch pathway is a fundamental signalling system in most multicellular animals. We have determined the X-ray crystal structure of the extracellular domain of the Notch ligand delta-like ligand-1 (...

Polyproline promotes tetramerization of recombinant human butyrylcholinesterase.

Biochem. J. 462(2) , 329-35, (2014)

Human BChE (butyrylcholinesterase) protects against the toxicity of organophosphorus nerve agents and pesticides. BChE purified from human plasma is limited and pathogen carry-over is a concern. Unlik...

A Chimeric HIV-1 gp120 Fused with Vaccinia Virus 14K (A27) Protein as an HIV Immunogen.

PLoS ONE 10 , e0133595, (2015)

In the HIV vaccine field, there is a need to produce highly immunogenic forms of the Env protein with the capacity to trigger broad B and T-cell responses. Here, we report the generation and character...

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