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氯(三乙基膦)金(I)

氯(三乙基膦)金(I)名称

[ CAS 号 ]:
15529-90-5

[ 中文名 ]:
氯(三乙基膦)金(I)

[ 英文名 ]:
CHLORO(TRIETHYLPHOSPHINE)GOLD(I)

[中文别名 ]:

(三乙基膦)氯化金(I)

[英文别名 ]:

Gold,chloro(triethylphosphine)
[Au(PEt3)Cl]
chloro(triethylphosphine)-gol
TRIETHYLPHOSPHINEGOLD I CHLORIDE
chloro(triethylphosphine)gold
[AuCl(PEt3)]
PEt3 gold(I) chloro complex
EINECS 239-572-3
MFCD00013205
Triethylphosphineaurous chloride

氯(三乙基膦)金(I)物理化学性质

[ 沸点 ]:
210ºC0.03 mm Hg(lit.)

[ 熔点 ]:
84-86ºC(lit.)

[ 分子式 ]:
C₆H₁₅AuClP

[ 分子量 ]:
350.57700

[ 闪点 ]:
27.2ºC

[ 精确质量 ]:
350.02700

[ PSA ]:
13.59000

[ LogP ]:
3.21500

[ 外观性状 ]:
crystal | white to pink

[ 储存条件 ]:
2-8°C，密闭，干燥

氯(三乙基膦)金(I)MSDS

氯(三乙基膦)金(I)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MD5431000

CHEMICAL NAME :: Gold, chloro(triethylphosphine)-

CAS REGISTRY NUMBER :: 15529-90-5

LAST UPDATED :: 199112

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C6-H15-Au-Cl-P

MOLECULAR WEIGHT :: 350.60

WISWESSER LINE NOTATION :: G-AU-UP3&3&3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 79 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 92560 ug/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 46280 ug/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 37500 nmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 34,3243,1985

氯(三乙基膦)金(I)安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
26-28-36/37/39-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
MD5431000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

氯(三乙基膦)金(I)合成路线

氯(三乙基膦)金(I)文献

Synthesis of thionato(triethylphosphine) gold(I) complexes:analogues of "auranofin," an antiarthritic drug.

J. Inorg. Biochem. 38(2) , 95-100, (1990)

New compounds having the formula [L-Au-PEt3]Cl (where L = imidazolidine-2-thione(Imt) and 1,3-Diazinane-2-thione(Diaz)) are synthesized. They are characterized by elemental analysis, infrared, 13C and...

Inhibition of human phospholipase C by aurothiomalate and (triethylphosphine) gold complexes.

Arzneimittelforschung 42(3) , 328-33, (1992)

The effect of several gold complexes on the activity of phospholipase C from human blood platelets was studied in vitro. Aurothiomalate and auranofin--2 agents used for the chrysotherapy of rheumatoid...

The structural flexibility of ferric cytochrome c: regulation of the spin-state equilibrium by an anti-arthritic gold(I) compound at neutral pH.

FEBS Lett. 116(2) , 227-30, (1980)

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