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Isolithocholic acid

Isolithocholic acid用途

异锂胆酸(β-石胆酸)是石胆酸的同分异构体。异胆酸是一种胆汁酸,由石胆酸或石胆酸3α-硫酸盐的微生物代谢形成[1][2]。

Isolithocholic acid名称

[ CAS 号 ]:
1534-35-6

[ 中文名 ]:
异石胆酸

[ 英文名 ]:
Isolithocholic Acid

[英文别名 ]:

3b-Hydroxy-5b-cholan-24-oic acid
3b-Lithocholic acid
3β-Hydroxy-5β-cholan-24-oic Acid
Cholan-24-oic acid, 3-hydroxy-, (3β,5β)-
Isolithocholic acid
(3β,5β)-3-Hydroxycholan-24-oic acid
(3β,5β,20R)-3-Hydroxycholan-24-oic acid
(3Î²,5Î²)-3-hydroxy-cholan-24-oic acid
Cholan-24-oic acid, 3-hydroxy-, (3β,5β,20R)-
MFCD00271385

Isolithocholic acid生物活性

[ 描述 ]:

异锂胆酸(β-石胆酸)是石胆酸的同分异构体。异胆酸是一种胆汁酸,由石胆酸或石胆酸3α-硫酸盐的微生物代谢形成[1][2]。

[ 相关类别 ]:

研究领域 >> 内分泌

[ 靶点 ]

Microbial Metabolite

[体外研究]

异乙醇酸在0.01%时不抑制CF5和M120的孢子萌发和生长,但在较高浓度(0.1%)时显著抑制。异乙醇酸(0.00003%)阻止CD196、M68、CF5、630和BI9的生长,并显著降低菌株CF5、BI9、M120和630的毒素活性。异乙醇酸(0.0003%)使除R20291和M120外的所有菌株的毒素活性显著降低[3]。

[体内研究]

与正常饮食喂养的大鼠相比,从第28天起,高脂饮食(HFD)组的粪便异乙醇酸水平明显降低[4]。

[参考文献]

[1]. Batta AK, et al. Transformation of bile acids into iso-bile acids by Clostridium perfringens: possible transport of 3 beta-hydrogen via the coenzyme. Hepatology. 1985;5(6):1126-1131.

[2]. Borriello SP, et al. The metabolism of lithocholic acid and lithocholic acid-3-alpha-sulfate by human fecal bacteria. Lipids. 1982;17(7):477-482.

[3]. Thanissery R, et al. Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids. Anaerobe. 2017;45:86-100.

[4]. Lin H, et al. Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model. J Agric Food Chem. 2019;67(13):3624-3632.